2013 Fiscal Year Final Research Report
Abscopal effect based on tumor immunology and revolutionary strategy of radiation therapy
| Project/Area Number |
23591837
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NIIBE Yuzuru 北里大学, 医学部, 講師 (00372912)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAGAWA Keiichi 東京大学, 医学部附属病院, 准教授 (80188896)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 腫瘍免疫 / アブスコパル / 放射線治療 |
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| Research Abstract |
Basic research using tumor-bearing mice via irradiation with immunostimulant agents was conducted. CD4+ cells, CD8+ cells and NK/NKT cells were identified as candicates of effector cells.
To consistent induction of abscopal effects, various combinations of irradiation of 6 Gy (6MeV-electron beam) with intravenous infusion of chemokine ECI301 after implantation of different tumor cells into bilateral flanks of BALB/c mice were conducted. We observed significant abscopal effects in several settings.
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[Journal Article] Independent absorbed-dose calculation using the Monte Carlo algorithm in volumetric modulated arc therapy2014
Author(s)
Haga A, Magome T, Takenaka S, Imae T, Sakumi A, Nomoto A, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
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Journal Title
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[Journal Article] Correlation among 16 biological factors [p53, p21(waf1), MIB-1 (Ki-67), p16(INK4A), cyclin D1, E-cadherin, Bcl-2, TNF-α, NF-κB, TGF-β, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1α] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma2013
Author(s)
Shibata-Kobayashi S, Yamashita H, Okuma K, Shiraishi K, Igaki H, Ohtomo K, Nakagawa K
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Journal Title
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[Journal Article] Dose verification of volumetric modulated arc therapy (VMAT) by use of in-treatment linac parameters2013
Author(s)
Haga A, Sakumi A, Okano Y, Itoh S, Saotome N, Kida S, Igaki H, Shiraishi K, Yamashita H, Ohtomo K, Nakagawa K
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Journal Title
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[Journal Article] Four-dimensional measurement of the displacement of internal fiducial and skin markers during 320- multislice computed tomography scanning of breast cancer2012
Author(s)
Yamashita H, Okuma K, Tada K, Shiraishi K,Takahashi W, Shibata-Mobayashi S, Sakumi A,Saotome N, Haga A, Onoe T, Ino K, Akahane M,Ohtomo K, Nakagawa K
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Journal Title
Int J Radiat Oncol Biol Phys
Pages: 331-5
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