2013 Fiscal Year Final Research Report
Comprehensive analysis of molecular factors that impact on radiation dose response using the Linear-quadratic model
Project/Area Number |
23591839
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Osaka University |
Principal Investigator |
SEO YUJI 大阪大学, 医学(系)研究科(研究院), 助教 (00302000)
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Project Period (FY) |
2011 – 2013
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Keywords | がん治療 / 放射線治療 / 定位放射線治療 / LQモデル / 放射線増感作用 / 線量依存性 |
Research Abstract |
In this study, I investigated an association between molecular factors and radiation dose response in 52 types of cancer cell lines using the Linear-quadratic model. The analysis revealed basal gene expression profiles and cancer gene mutation status that impact on the cellular response to a high-dose radiation per fraction compared with a lower-dose radiation. In addition, drug-radiation interactions were analyzed when radiation was given at a high dose versus low dose per fraction. The results suggested that there are several molecular targets and radiosensitizing agents that may affect treatment outcomes in a high-precision hypofractionated radiotherapy.
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Research Products
(1 results)