Development of a dose conversion model applicable to single and hypofractionated irradiation

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591846
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: SHIBAMOTO Yuta 名古屋市立大学, 医学(系)研究科(研究院), 教授 (20144719)
• Co-Investigator(Kenkyū-buntansha): SUGIE Chikao 名古屋市立大学, 大学院・医学研究科, 准教授 (80509258)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: LQモデル / BED / 再酸素化

Outline of Final Research Achievements

This study aimed to develop a dose conversion model that is applicable to single and hypofractionated irradiation. Using the linear-quadratic model, EMT6 cells were irradiated to the same biological effective dose (BED) with various fractionation schedules. Despite the same BED, the effects of 1 to 5 fractions of irradiation were significantly lower than those of 7 or more fraction irradiation. Thus, the LQ model was considered only applicable to 7 or more fraction irradiation. It was concluded that the BED overestimates the biological effects of hypofractionated doses. An ideal model to convert the dose was difficult. However, by discounting 15-20% of the BED calculated using the LQ model, it was considered that actual biological effects could be roughly predicted.

Free Research Field

放射線生物学