2014 Fiscal Year Final Research Report
Development of a dose conversion model applicable to single and hypofractionated irradiation
Project/Area Number |
23591846
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Nagoya City University |
Principal Investigator |
SHIBAMOTO Yuta 名古屋市立大学, 医学(系)研究科(研究院), 教授 (20144719)
|
Co-Investigator(Kenkyū-buntansha) |
SUGIE Chikao 名古屋市立大学, 大学院・医学研究科, 准教授 (80509258)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Keywords | LQモデル / BED / 再酸素化 |
Outline of Final Research Achievements |
This study aimed to develop a dose conversion model that is applicable to single and hypofractionated irradiation. Using the linear-quadratic model, EMT6 cells were irradiated to the same biological effective dose (BED) with various fractionation schedules. Despite the same BED, the effects of 1 to 5 fractions of irradiation were significantly lower than those of 7 or more fraction irradiation. Thus, the LQ model was considered only applicable to 7 or more fraction irradiation. It was concluded that the BED overestimates the biological effects of hypofractionated doses. An ideal model to convert the dose was difficult. However, by discounting 15-20% of the BED calculated using the LQ model, it was considered that actual biological effects could be roughly predicted.
|
Free Research Field |
放射線生物学
|