2013 Fiscal Year Final Research Report
Mechanism elucidation of proton beam specific cellular response for radiation therapy
| Project/Area Number |
23591854
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The Wakasa Wan Energy Research Center |
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Principal Investigator |
HATASHITA masanori 公益財団法人若狭湾エネルギー研究センター, 研究開発部, 主任研究員 (40359237)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Hideki 福井大学, 高エネルギー医学研究センター, 准教授 (40142377)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 量子ビーム / イオンビーム / 突然変異 / 放射線感受性 |
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| Research Abstract |
The differences in mutation induction and mutation spectrum between proton beams and X-rays in human cells were investigated. Cell killing effect was almost the same between proton beams and X-rays, while a difference in mutation frequency was observed and the frequency of hprt mutation of cells irradiated with proton beams was lower than that of cells irradiated with X-rays. Furthermore, the deletion spectrum of exons was different in induced mutants between proton beams and X-rays. These findings suggest that there are quantitative and qualitative differences in mutation induction between proton beams and X-rays even if the RBE values are similar.
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Research Products
(6 results)
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[Journal Article] Regulation of gene expression in retrovirus vectors by X-ray and proton beam radiation with artificially constructed promoters2012
Author(s)
R. Ogawa, A. Morii, A. Watanabe, Z.-G. Cui, Kagiya, S. Fukuda, K. Kume, T. Hasegawa, M. Hatashita, H. Izumi, T. Ishimoto, L. B. Feril Jr
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Journal Title
The Journal of Gene Medicine.
Volume: 14(5)
Pages: 316-327
DOI
Peer Reviewed
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