2013 Fiscal Year Final Research Report
The evaluation of sepsis by new endotoxin detection methods
| Project/Area Number |
23591863
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Hiroshi 滋賀医科大学, 医学部, 講師 (00283557)
TANI Toru 滋賀医科大学, 医学部, 教授 (20179823)
OBATA Toru 滋賀医科大学, 医学部, 特任准教授 (80119776)
RGUCHI Yutaka 滋賀医科大学, 医学部, 教授 (00263054)
TABATA Takahisa 滋賀医科大学, 医学部, 講師 (90278200)
AKABORI Hiroya 滋賀医科大学, 医学部, 特任助教 (10340069)
MIYAKE Tohru 滋賀医科大学, 医学部, 客員助教 (70581924)
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| Project Period (FY) |
2011 – 2013
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| Keywords | エンドトキシン / 敗血症性ショック / 敗血症 / 高感度測定 |
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| Research Abstract |
Endotoxin Laser Scattering Photometry (ESP) method may more sensitively detect endotoxins than the ordinary turbidimetric method. ESP significantly discriminated between patients with or without septic shock and sepsis compared to the ordinary method. There was no significant difference in predictive power between ESP and procalcitonin test that is one of common tools for the diagnosis of bacterial infection. The patients clinical conditions of septic shock due to intra-abdominal infection were improved by endotoxin adsorption therapy (PMX), reducing plasma endotoxins measured by ESP method. We also observed the reduction in the endotoxin after passing through column by ESP method even after the longer duration of PMX.
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[Journal Article] ETRF/UFの多段化で透析液の微生物学的清浄度は向上するか?2013
Author(s)
大薗英一,小幡徹,井上有紀,本田和美,熊谷拓也,根岸秀樹,市村恭子,岡松健太郎,滝澤英明,野呂瀬嘉彦,高橋めぐみ,清水智治,谷徹,冨岡敏一,坂元仁,土戸哲明:岡松健太郎,滝澤英明,野呂瀬嘉彦,高橋めぐみ
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Journal Title
腎と透析
Volume: 75巻別冊
Pages: 139-141
Peer Reviewed
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[Journal Article] 高感度エンドトキシン測定ESP法を用いた透析液のエンドトキシン測定と培養検査の多施設比較2013
Author(s)
小幡徹,清水智治,谷徹,上村優介,清水洋一,中澤了一,柏原英彦,森戸勝,佐藤寿加,井上均,木次谷隆公,市川正人,竹内一郎,吉岡豊一,吉田和彦
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Journal Title
腎と透析
Volume: 75巻別冊
Pages: 122-124
Peer Reviewed
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[Journal Article] 消化器外科手術でのEndotoxin activity assay(EAA)の変動に関する検討2012
Author(s)
赤堀浩也,清水智治,三宅亨,山口剛,園田寛道,塩見尚礼,仲成幸,村田聡,山本寛,小幡徹,遠藤善裕,谷徹
Volume
16巻
Pages
93-102
Peer Reviewed
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