2013 Fiscal Year Final Research Report
Next generation prosthetic vascular graft with small diameters developed using new tissue engineering technology
| Project/Area Number |
23591867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Sigeki 佐賀大学, 医学部, 教授 (70243938)
NODE Kouichi 佐賀大学, 医学部, 教授 (80359950)
NAKAYAMA Kouichi 佐賀大学, 工学系研究科, 教授 (50420609)
NOGUCHI Ryo 佐賀大学, 医学部, 助教 (70530187)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生医療 / 人工臓器 / 人工血管 |
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| Research Abstract |
We developed a new tissue engineering technology that enables the creation of a three-dimensional cellular structure with any shape using only cells. In this technology, a three-dimensional culture is generated using the natural aggregating ability of cells, focusing on cell aggregates (spheroids). A robot (Scaffold-free 3D BioFabrication system) constructs a complex three-dimensional structure using a cell aggregate (spheroid) as one unit. We used these cell aggregates to successfully create vascular structures which were transplantable into abdominal aortas (1-1.5 mm diameters) in nude mice. In the acute phase after transplantation, the patency of vascular structures was verified. Histopathological examination showed that the lumens of vascular structures were covered with vascular endothelial cells that were positive for the von Willebrand factor.
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