2013 Fiscal Year Final Research Report
Mechanism of Cytomegalovirus reactivation after organ transplantation
| Project/Area Number |
23591876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Showa University |
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Principal Investigator |
TANAKA Kazuo 昭和大学, 医学部, 教授 (50236569)
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| Project Period (FY) |
2011 – 2013
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| Keywords | サイトメガロウイルス / ウイルス再活性化 / 臓器移植 |
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| Research Abstract |
Aim of this study is to clarify the mechanism of cytomegalovirus (CMV) reactivation after organ transplantation. For this purpose, we developed in vitro and in vivo CMV reactivation models. In in vitro model, two macrophage-derived cell lines were used, and then the cell differentiation and acetylation of histone in CMV infected cells were demonstrated to be critical in CMV reactivation. In in vivo model, we demonstrated the CMV reactivation in the milk of breast-feeding female mice. Interestingly, reactivated CMV titers in the breast milk was much higher in syngeneic pregnancy than those in allogeneic pregnancy, suggesting that allogeneic stimuli is unnecessary in CMV reactivation.
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Research Products
(8 results)
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[Journal Article] Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-〱and interleukin-1Ⓡ,but suppresses that by interleukin-17A.
Importance of proteolytic degradation of osteoprotegerin by lysine gingipain2014
Author(s)
Akiyam A, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, and Kamijo R
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Journal Title
J.Biolol. Chemi
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Low HCMV DNA Copies Can Establish Infection and Result in Significant Symptoms in Extremely Preterm Infants : A Prospective Study2012
Author(s)
Wakabayashi H, Mizuno K, Kohda C, Negoro T, Maekawa C, Sawato S, Tanaka K, Nakano Y, Murayama J, Taki M, Miyazawa T, Murase M, Aizawa M, Nakano Y, Sakurai M, Takahashi K, Itabashi K
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Journal Title
Am J Perinatol
Volume: 29(5)
Pages: 377-82
Peer Reviewed
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