2013 Fiscal Year Final Research Report
Inflammation in rat liver transplantation model
| Project/Area Number |
23591881
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
ISHII Eiichi 日本医科大学, 医学(系)研究科(研究院), 研究員 (00193243)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Akira 日本医科大学, 医学部, 教授 (00256942)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 移植 / 肝臓移植 / ラット / 拒絶反応 / 抗体依存性拒絶反応 / 細胞性拒絶反応 / 肝動脈再建 / 急性腎障害 |
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| Research Abstract |
In the present study, we studied experimental orthotopic liver transplantation (OLT) model. We recognized that the Kamada technique and a new splint technique for hepatic artery reconstruction was convenient technique for rat OLT. We demonstrated that hepatic artery reconstruction prevented ischemic graft injury, inhibited graft rejection, and mediated long-term graft acceptance in rat OLT. In rejection of OLT, acute antibody-mediated rejection (AMR) clould develop in OLT and was characterized by endothelial cell injuries in microvasculature and by bile duct and hepatic cell degeneration and necrosis. In addition, chronic AMR could also involve in chronic rejection in OLT, and was characterized by typical late morphological changes with IgG deposition. In the development of tolerance in OLT, lymphangiogenesis may be involved in reduction of inflammation. Now we are studying the pathological characteristics of immune tolerance in rat OLT model.
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Research Products
(18 results)
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[Journal Article] Hepatic artery reconstruction prevents ischemic graft injury, inhibits graft rejection, and mediates long-term graft acceptance in rat liver transplantation2013
Author(s)
Ishii E, Shimizu A, Kuwahara N, Kanzaki G, Higo S, Kajimoto Y, Arai T, Nagasaka S, Masuda Y, Fukuda Y
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Journal Title
Transplant Proc
Volume: 45
Pages: 1748-1753
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[Journal Article] Renal inflammatory changes in acute hepatic failure-associated acute kidney injury2013
Author(s)
Shimizu A, Ishii E, Masuda Y, Sato A, Piao A, Kunugi S, Takahashi M, Terasaki M, Nagasaka S, Terasaki Y, Ohashi R, Morioka T, Fukuda Y
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Journal Title
Am J Nephrol
Volume: 37
Pages: 378-388
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[Presentation] Impaired renal microcirculation in hepatic failure-associated acute kidney injury in rats2013
Author(s)
Shimizu A, Ishii E, Masuda Y, Sato A, Piao H, Kunugi S, Takahashi M, Terasaki M, Nagasaka S, Terasaki Y, Ohashi R, Morioka T, Fukuda Y
Organizer
ASN Kidney Week 2013
Place of Presentation
Atlanta
Year and Date
20131100
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[Presentation] Transplantation Biology Research Center, Massachusetts General Hospital, Boston, USA): Renal peritubular capillary injury with impaired renal microcirculation in hepatic acute kidney injury in rats2012
Author(s)
Shimizu A, Ishii E, Masuda Y, Piao H1), Kuwahara N, Ishikawa A, Arai T, Morioka T1), Fukuda Y(1)
Organizer
ASN Kidney Week 2012
Place of Presentation
San Diego
Year and Date
20121100
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[Presentation] Hepatic artery reconstruction precents ischemic graft injury, inhibits graft rejection, and mediates long-term graft acceptance in rat liver transplantation2012
Author(s)
Ishii E, Shimizu A, Kuwahara N, Kanzaki G, Higo S, Kajimoto Y, Nagasaka S, Masuda S, Fukuda Y
Organizer
24th International congress of the transplantation society
Place of Presentation
Berlin
Year and Date
20120600
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