Clinical significance of lymph node metastasis detected by OSNA and its application for breast cancer treated with neoadjuvant chemotherapy

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591893
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2012-2013); Osaka University (2011)
• Principal Investigator: TAMAKI Yasuhiro 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他(副院長) (10273690)
• Co-Investigator(Kenkyū-buntansha): SHIMAZU Kenzo 大阪大学, 医学(系)研究科(研究院), 講師 (30448039)
• Project Period (FY): 2011 – 2013
• Keywords: 乳癌 / センチネルリンパ節 / OSNA / 術前化学療法 / 転移予測

Research Abstract

Study 1. Usefulness of OSNA for detection of lymph node metastasis in breast cancer patients treated with neoadjuvant chemotherapy was examined. Lymph nodes obtained from 92 patients operated between September 2011 and September 2013 were sliced into 4 pieces, and examined with pathology and OSNA. Sensitivity, specificity and negative predictive value of OSNA for pathology were 84.4%, 93.5% and 95.8% respectively. In breast cancer patients treated with neoadjuvant chemotherapy who undergo sentinel lymph node biopsy, axillary dissection can be avoided if sentinel lymph nodes are negative for metastasis with OSNA.
Study 2. A nomogram to predict non-sentinel lymph node metastasis was created based on results of OSNA obtained from 833 breast cancer patients who underwent sentinel lymph node biopsy and axillary dissection. Accuracy of our model was 0.704 indicated by ROC curve, and the nomogram using OSNA can be used for intraoperative prediction of non-sentinel lymph node metastasis.

Research Products

• [Journal Article] One-Step Nucleic Acid Amplification Assay for Intraoperative Prediction of Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Sentinel Lymph Node Metastasis
  • Author(s): Atsuko Teramoto, Kenzo Shimazu, Yasuto Naoi, Atsushi Shimomura, Masafumi Shimoda, Naofumi Kagara, Naomi Maruyama, Seung Jin Kim, Katsuhide Yoshidome, Masahiko Tsujimoto, Yasuhiro Tamaki, Shinzaburo Noguchi
  • Journal Title: The Breast