2014 Fiscal Year Final Research Report
Establishment of the animal model of lymphangioma using human lymphangioma derived lymphatic endothelial cell
| Project/Area Number |
23591917
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Keio University (2012-2014)
National Research Institute for Child Health and Development (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UMEZAWA Akihiro 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 部長 (70213486)
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| Co-Investigator(Renkei-kenkyūsha) |
HATA Jyunichi 独立行政法人国立成育医療研究センター, 名誉総長 (90051614)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | リンパ管腫 / リンパ管奇形 / モデル動物 / リンパ管内皮細胞 / 細胞生物学 / 病態発生 / 新規治療法 |
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| Outline of Final Research Achievements |
The purposes of this study were the elucidation of the mechanism for the pathogenesis of lymphangioma, the exploration of seeds for new therapeutic methods for the disease, and establishment of animal model of the lymphangioma necessary to examine the new therapeutic methods.
In this study, we established technique to make lymphangioma-like lesion in the NOG mouse by transplanting primary culture cells derived from lymphangioma lesions. In addition, we succeeded in immortalizing this cell, and introducing the fluorescence and light emission protein. We need to continue this project it in order to make an animal model in which the lesion is observable from the outside the body by transplanting this cell.
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| Free Research Field |
小児外科、リンパ管疾患
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