2013 Fiscal Year Final Research Report
Expression and functional analysis of miR-203 related to proliferation, invasion, and metastasis in esophageal cancer
| Project/Area Number |
23591918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
MORI Mikito 千葉大学, 医学部附属病院, 助教 (90399452)
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| Co-Investigator(Kenkyū-buntansha) |
AKUTSU Yasunori (00375677)
KAWAHIRA Hiroshi 千葉大学, フロンティア医工学センター, 准教授 (90447285)
SUZUKI Kazufumi 千葉大学, 医学部附属病院, 助教 (00586737)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUBARA Hisahiro 千葉大学, 大学院医学研究院, 教授 (20282486)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 食道外科学 / マイクロRNA |
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| Research Abstract |
To elucidate how miR-203 is related to proliferation, invasion, and metastasis of esophageal cancer, we performed the expression and functional analysis of miR-203. We found that the expression of miR-203 may be related to invasion, and metastasis of esophageal cancer cell. In further investigation, We also identified 22 genes controlled by miR-203 in esophageal cancer cell using DNA microarray analysis. We found that LASP1, which was one of 22 genes that we identified in our study, was directly controlled by miR-203, and might be related to the mechanism of invasion, and metastasis in esophageal cancer cell. From these results, we concluded the difference of miR-203 expression in esophageal cancer cell may influence the outcome of treatment of the patients with esophageal cancer.
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