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2013 Fiscal Year Final Research Report

A randomized controlled trial to establish a standard method for reconstruction after total gastrectomy

Research Project

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Project/Area Number 23591925
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionNagoya University

Principal Investigator

KODERA Yasuhiro  名古屋大学, 医学(系)研究科(研究院), 教授 (10345879)

Co-Investigator(Kenkyū-buntansha) MORITA Satoshi  京都大学, 大学院医学系研究科, 教授 (60362480)
YOSHIKAWA Takaki  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 消化器外科, 部長 (30336573)
ITO Yuichi  愛知県がんセンター(研究所), 腫瘍病理学部, 研究員 (80397463)
Project Period (FY) 2011 – 2013
Keywords胃全摘術 / 再建法 / 胃癌 / 空腸パウチ
Research Abstract

Total gastrectomy substantially affects ongeneral status and quality of life through difficulty in food consumption. Recently, aboral pouch reconstruction (AP reconstruction) was reported in which reconstruction with a jejunal pouch can be performed easily using one extra set of linear staplers. In order to evaluate the efficacy and safety of this method, 100 patients who underwent R0 resection by total gastrectomy were randomized into either AP reconstruction or Roux-Y, and comparisons were made with various endpoints. No differences were found in operating time, amount of blood loss, morbidity and length of postoperative hospital stay, indicating that the AP reconstruction is safe. AP reconstruction was superior in terms of several items included in the EORTC QLQ-C30 questionnaire and lean body mass, but these differences did not reach statistical significance at one year after surgery. Further followup was deemed necessary, another survey at 3 years postoperatively.

  • Research Products

    (12 results)

All 2014 2013 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results)

  • [Journal Article] 腹腔鏡下胃全摘術におけるY脚空腸パウチ・Roux-Y再建2013

    • Author(s)
      三澤一成、伊藤誠二、伊藤友一、清水泰博、木下平
    • Journal Title

      手術

      Volume: 第67巻5号 Pages: 559-566

    • Peer Reviewed
  • [Journal Article] Assessment of quality of life after gastrectomy using EORTC QLQ-C30 and STO222011

    • Author(s)
      Kobayashi D, Kodera Y, Fujiwara M, Koike M, Nakayama G, Nakao A.
    • Journal Title

      Would Journal of Surgery

      Volume: 35(2) Pages: 357-64

    • Peer Reviewed
  • [Journal Article] Nutritional recovery after open and laparoscopic gastrectomies2011

    • Author(s)
      Abdiev S, Kodera Y, Fujiwara M, Koike M, Nakayama G, Ohashi N, Tanaka C, Sakamoto J, Nakao A.
    • Journal Title

      Gastric Cancer

      Volume: 14(2) Pages: 144-9

    • Peer Reviewed
  • [Presentation] 胃全摘におけるR-Y再建とAboral pouch再建を比較する第III相試験2014

    • Author(s)
      伊藤友一他9名
    • Organizer
      第86回日本胃癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-03-22
  • [Presentation] 腹腔鏡下胃全摘(LATG)術後の再建法~Endo-stitch用いた食道空腸吻合とY脚空腸パウチ作成2013

    • Author(s)
      伊藤友一他12名
    • Organizer
      第26回日本内視鏡外科学会総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2013-11-29
  • [Presentation] 胃全摘におけるR-Y再建とAboral pouch再建を比較する第III相試験2013

    • Author(s)
      伊藤友一他2名
    • Organizer
      第11回日本消化器外科学会大会
    • Place of Presentation
      グランドプリンスホテル新高輪・国際館パミール(東京都港区)
    • Year and Date
      2013-10-11
  • [Presentation] valuation of Aboral Pouch Reconstruction After Total Gastrectomy in Patients with Gastric Cancer : A Prospective Randomized Controlled Trial2013

    • Author(s)
      Y. Kodera, et al. (他9名)
    • Organizer
      American College of Surgeons 99th Clinical Congress
    • Place of Presentation
      Washington, USA
    • Year and Date
      2013-10-07
  • [Presentation] A comparison of postoperative quality of life after open and laparoscopic gastrectomy for early gastric cancer : A multicenter, nonrandomized, controlled study (CCOG 0802)2013

    • Author(s)
      C. Tanaka, K. Misawa, M, Fujiwara, S. Ito, Y. Mochizuki, D. Kobayashi, Y. Yamamura, M. Ando, S. Morita, Y. Kodera.
    • Organizer
      American Society of Clinical Oncology 2013 Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2013-06-02
  • [Presentation] Detailed Analysis of QOL after Laparoscopy-Assisted Gastrectomy2012

    • Author(s)
      Y. Kodera, et al. (他8名)
    • Organizer
      22nd World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2012-12-06
  • [Presentation] 早期胃癌の術後QOLに関する腹腔鏡下vs開腹手術比較他施設共同試験(CCOG0802)2012

    • Author(s)
      西鉄生、藤原道隆、渡邉卓哉、三澤一成、今村博司、望月能成、石槫清、石山聡治、高瀬恒信、江口武彦、森岡祐貴、木下敬史、伊藤誠二、山村義孝、小寺泰弘
    • Organizer
      第74回日本臨床外科学会総会
    • Place of Presentation
      京王プラザホテル(東京新宿区)
    • Year and Date
      2012-12-01
  • [Presentation] 胃全摘後のR-Y再建におけるY脚パウチ作成法2012

    • Author(s)
      伊藤友一他9名
    • Organizer
      第67回日本消化器外科学会総会
    • Place of Presentation
      富山国際会議場(富山市)
    • Year and Date
      2012-07-18
  • [Presentation] 早期胃癌に対する腹腔鏡下胃切除の術後quality of lifeの検討2011

    • Author(s)
      渡邉卓哉、小寺泰弘他8名
    • Organizer
      第73回日本臨床外科学会総会
    • Place of Presentation
      京王プラザホテル(東京新宿区)
    • Year and Date
      2011-11-19

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Published: 2015-07-16  

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