Target therapy against DNA repair system for esophageal cancer

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591938
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: National Hospital Organization, Kyushu Cancer Center (2012-2013); Kyushu University (2011)
• Principal Investigator: EGASHIRA Akinori 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他 (00419524)
• Co-Investigator(Kenkyū-buntansha): KAKEJI Yoshihiro (80284488) ; MORITA Masaru (30294937) ; OHGA Takefumi (60335958) ; SONODA Hideto (00465725)
• Project Period (FY): 2011 – 2013
• Keywords: 食道癌 / DNA修復 / 標的治療

Research Abstract

Although the prognosis of esophageal cancer is poor, the therapeutic outcome is getting better by multimodal treatment. The purpose of this study is to clarify the molecular mechanism of DNA repair deficiency in esophageal cancer and develop the molecular targeting therapy against these pathways.
By analyzing the level of 8-OHdG and OGG1 enzyme, oxidative DNA damage, which is attributable to smoking as well as disturbances in DNA repair systems, appears to be closely related to esophageal carcinogenesis and its progression. By analyzing RAD51 expression, DNA double strand break repair deficiency seems to be associated with poor survival and might be a predictive factor for the response to neoadjuvant therapy.

Research Products

• [Journal Article] Oxidative DNA damage in human esophageal cancer : clinicopathological analysis of 8-hydroxydeoxyguanosine and its repair enzyme (2014)
  • Author(s): Kubo N, Morita M, Nakashima Y, Kitao H, Egashira A, Saeki H, Oki E, Kakeji Y, Oda Y, Maehara Y.
  • Journal Title: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / ISDE 2014 Volume: 27(3) Pages: 285-293
• [Journal Article] Gender differences in prognosis after esophagectomy for esophageal cancer (2014)
  • Author(s): Morita M, Otsu H, Kawano H, Kasagi Y, Kimura Y, Saeki H, Ando K, Ida S, Oki E, Tokunaga E, et al.
  • Journal Title: Surgery today Volume: 44(3) Pages: 505-512
• [Journal Article] Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus (2014)
  • Author(s): Nakanoko T, Saeki H, Morita M, Nakashima Y, Ando K, Oki E, Ohga T, Kakeji Y, Toh Y, Maehara Y.
  • Journal Title: Annals of surgical oncology Volume: 21(2) Pages: 597-604
• [Journal Article] Surgical resection for esophageal cancer synchronously or metachronously associated with head and neck cancer (2013)
  • Author(s): Morita M, Kawano H, Otsu H, Kimura Y, Saeki H, Ando K, Ida S, Oki E, Ikeda T, Kusumoto T, et al.
  • Journal Title: Annals of surgical oncology Volume: 20(7) Pages: 2434-2439
• [Journal Article] Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion (2013)
  • Author(s): Nakashima Y, Yoshinaga K, Kitao H, Ando K, Kimura Y, Saeki H, Oki E, Morita M, Kakeji Y, Hirahashi M, et al.
  • Journal Title: Cancer science Volume: 104(12) Pages: 1718-1725
• [Journal Article] Multimodal treatment strategy for clinical T3 thoracic esophageal cancer (2013)
  • Author(s): Saeki H, Morita M, Tsuda Y, Hidaka G, Kasagi Y, Kawano H, Otsu H, Ando K, Kimura Y, Oki E, et al.
  • Journal Title: Annals of surgical oncology Volume: 20(13) Pages: 4267-4273
• [Journal Article] Epigenetic alterations and their clinical implications in esophageal squamous cell carcinoma (2013)
  • Author(s): Toh Y, Egashira A, Yamamoto M.
  • Journal Title: General thoracic and cardiovascular surgery Volume: 61(5) Pages: 262-269
• [Journal Article] Successful treatment of primary jejunal cancer after esophageal and colon cancer resection
  • Author(s): Egashira A, Taguchi K, Toh Y, Yamamoto M, Okamura T, Saeki H, Oki E, Morita M, Ikeda T, Mimori K, et al.
  • Journal Title: Fukuoka igaku zasshi = Hukuoka acta medica Volume: 104(11) Pages: 435-441
• [Presentation] Clinical outcomes and problems of definitive chemoradiotherapy for esophageal cancer (2014)
  • Author(s): Akinori Egashira, Yasushi Toh, Manabu Yamamoto, Kippei Ohgaki, Syohei Yamaguchi, Kazuhito Minami, Naonobu Kunitake, Kazuhiro Okushima and Takeshi Okamura
  • Organizer: 18<th> WCBIP/WCBE
  • Place of Presentation: Kyoto
  • Year and Date: 2014-04-15
• [Presentation] 他臓器浸潤(T4)食道癌に対する集学的治療の検討 (2014)
  • Author(s): 江頭明典、藤也寸志、上江洌一平、藤家雅志、大垣吉平、金城直、山口将平、前原伸一郎、山本学、南一仁、池田泰治、岡村健
  • Organizer: 第114回日本外科学会定期学術総会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-05
• [Presentation] 食道切除再建術における腹腔鏡補助下胃管作成 (2013)
  • Author(s): 江頭明典、大垣吉平、金城直、山口将平、前原伸一郎、山本学、南一仁、池田泰治、藤也寸志、岡村健
  • Organizer: 第26回日本内視鏡外科学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2013-11-28
• [Presentation] 同時性頭頸部癌合併食道癌の臨床病理学的特徴と治療法についての検討 (2013)
  • Author(s): 江頭明典、上江洌一平、藤家雅志、大垣吉平、金城直、山口将平、前原伸一郎、山本学、南一仁、池田泰治、藤也寸志、岡村健
  • Organizer: 第65回日本気管食道科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2013-11-01
• [Presentation] 食道癌に対する根治的化学放射線療法の治療成績と問題点 (2013)
  • Author(s): 江頭明典、藤也寸志、上江洌一平、藤家雅志、大垣吉平、前原伸一郎、山本学、南一仁、池田泰治、岡村健
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2013-10-25
• [Presentation] T4食道癌に対する治療戦略と成績 (2013)
  • Author(s): 江頭明典、上江洌一平、藤家雅志、大垣吉平、前原伸一郎、山本学、南一仁、池田泰治、藤也寸志、岡村健
  • Organizer: 第66回日本胸部外科学会定期学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2013-10-17
• [Presentation] 食道神経内分泌癌の診断および治療 (2013)
  • Author(s): 江頭明典、藤家雅志、上江洲一平、大垣吉平、前原伸一郎、山本学、南一仁、池田泰治、坂口善久、藤也寸志、岡村健
  • Organizer: 第24回日本消化器癌発生学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2013-09-06
• [Presentation] 当院での食道癌治療における緩和医療の関わり (2013)
  • Author(s): 江頭明典、藤也寸志、大垣吉平、前原伸一郎、根東順子、山本学、南一仁、池田泰治、坂口善久、岡村健
  • Organizer: 第68回日本消化器外科学会定期学術総会
  • Place of Presentation: 宮崎
  • Year and Date: 2013-07-17
• [Presentation] 食道癌集学治療における緩和医療が果たす役割 (2013)
  • Author(s): 江頭明典、大垣吉平、前原伸一郎、根東順子、山本学、南一仁、池田泰治、坂口善久、藤也寸志、岡村健
  • Organizer: 第18回日本緩和医療学会学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-06-21
• [Presentation] 進行食道癌に対する術前化学療法および術前化学放射線療法の検討 (2013)
  • Author(s): 江頭明典、藤也寸志、藤家雅志、岩永彩子、大垣吉平、前原伸一郎、根東順子、山本学、南一仁、池田泰治、坂口善久、岡村健
  • Organizer: 第67回日本食道学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2013-06-13
• [Presentation] 進行食道癌に対する集学的治療 (2013)
  • Author(s): 江頭明典、藤也寸志、藤家雅志、岩永彩子、大垣吉平、前原伸一郎、根東順子、山本学、南一仁、池田泰治、坂口善久、藤也寸志、岡村健
  • Organizer: 第113回日本外科学会定期学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2013-04-13
• [Presentation] PALLIATIVE THERAPY FOR ADVANCED ESOPHAGEAL CANCER (2013)
  • Author(s): Akinori Egashira, Yasushi Toh, Manabu Yamamoto, Kippei Ohgaki, Kazuhito Minami, Yoshihisa Sakaguchi, Takeshi Okamura
  • Organizer: 21th Annual meeting of the Asian Society for Cardiovascular and Thoracic Surgery
  • Year and Date: 2013-04-06
• [Presentation] 食道癌に対する術前補助化学療法の効果予測に向けて (2012)
  • Author(s): 江頭明典、藤家雅志、岩永彩子、大垣吉平、前原伸一郎、根東順子、山本学、南一仁、池田泰治、坂口善久、藤也寸志、岡村健
  • Organizer: 第23回日本消化器癌発生学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2012-11-15
• [Presentation] 進行食道癌に対する術前補助化学療法の検討 (2012)
  • Author(s): 江頭明典、藤家雅志、岩永彩子、大垣吉平、前原伸一郎、根東順子、山本学、南一仁、池田泰治、坂口善久、藤也寸志、岡村健
  • Organizer: 第64回日本気管食道科学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-08
• [Presentation] 進行食道癌に対する術前補助化学療法の有用性の検討 (2012)
  • Author(s): 江頭明典、藤家雅志、岩永彩子、大垣吉平、前原伸一郎、根東順子、山本学、南一仁、池田泰治、坂口善久、藤也寸志、岡村健
  • Organizer: 第50回癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-10-25
• [Presentation] 三角吻合法による頸部食道胃管吻合術についての検討 (2012)
  • Author(s): 江頭明典、藤家雅志、岩永彩子、大垣吉平、前原伸一郎、根東順子、山本学、南一仁、池田泰治、坂口善久、藤也寸志、岡村健
  • Organizer: 第65回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-10-19
• [Presentation] 同時性食道・頭頸部重複癌の臨床的特徴と治療成績 (2012)
  • Author(s): 江頭明典、森田勝、藤也寸志、大垣吉平、前原伸一郎、南一仁、池田泰治、坂口善久、檜垣雄一郎、岡村健
  • Organizer: 第66回日本食道学会学術集会
  • Place of Presentation: 軽井沢
  • Year and Date: 2012-06-22