2013 Fiscal Year Final Research Report
The study of the function of miR-128b in ESCC cells
| Project/Area Number |
23591943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
MITSUI Akira 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (10405178)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Takahiro 名古屋市立大学, 医学(系)研究科(研究院), 助教 (90592501)
SHIOZAKI Midori 名古屋市立大学, 医学(系)研究科(研究院), 助教 (90531004)
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| Project Period (FY) |
2011 – 2013
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| Keywords | lipofection / RT-PCR / western blot / 移植 |
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| Research Abstract |
In the process of studying the mechanism by which miR-128b influences the survival rate of esophageal squamous cell carcinoma (ESCC) patients, we focused on Girdin, Akt substrate which is involved in the migration of cells. In the examination of the role of Girdin in ESCC, it was suggested that Girdin is involved in the migration of ESCC as well. In experiments using specimens of ESCC, ESCC tumors whose Girdin expresson is high tends to invade deeper. In addition, the 5-year survival rate of the ESCC patients whose Girdin expression is high declined more significantly. Therefore, in ESCC, Girdin may be a prognostic marker and may serve as a therapeutic target as well.
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Research Products
(29 results)
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[Journal Article] Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer2014
Author(s)
Tsuboi K, Matsuo Y, Shamoto T, Shibata T, Koide S, Morimoto M, Guha S, Sung B, Aggarwal BB, Takahashi H, Takeyama H.
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Journal Title
Oncol Rep.
Volume: 31(peer reviewed)
Pages: 51-64
DOI
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[Journal Article] Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma2013
Author(s)
Shibata T, Matsuo Y, Shamoto T, Hirokawa T, Tsuboi K, Takahashi H, Ishiguro H, Kimura M, Takeyama H, Inagaki H.
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Journal Title
Oncol Rep.
Volume: 29(peer reviewed)
Pages: 2127-2132
DOI
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[Journal Article] Two long-term survivors of gastric small cell carcinoma and examine the prognostic factor by using immnohistochemical analysis2011
Author(s)
Funahashi H, Wakasugi T, Shiozaki M, Ogawa R, Hara M, Ochi N, Sakamoto M, Matsuo Y, Mitsui A, Takayama S, Kimura M, Sato M, Okada Y, Kuwabara Y, Takeyama H.
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Journal Title
9th International Gastric Cancer Congress
Pages: 109-113
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[Presentation] PTEN down-regulates the VEGF expression and angiogenesis in pancreatic cancer2013
Author(s)
Matsuo Y, Shibata T, Tsuboi K, Shamoto T, Nagasaki T, Morimoto M, Ochi N, Takahashi H, Ishiguro H, Funahashi H, Sato M, Okada Y, Takeyama H.
Organizer
IAP&KPBA 2013
Place of Presentation
Sheraton Grande Walkerhill Hotel(Seoul, Korea)
Year and Date
20130904-07
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