2013 Fiscal Year Final Research Report
New development of a selective oncolytic virotherapy for gastric cancer
| Project/Area Number |
23591946
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 胃癌 / ウイルス療法 / オートファジー / サイトカインシグナル |
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| Research Abstract |
We developed recombinant oncolytic herpes simplex viruses that possess certain antitumor functions and are useful for gastric cancer therapy. A third-generation oncolytic herpes simplex virus type 1(T-01) was used as the backbone to insert foreign sequences. Oncolytic herpes simplex viruses expressing suppressor of cytokine signaling 3 (T-SOCS-3) were constructed, evaluated, and proved to be therapeutic potential. T-SOCS-3 may be a new agent against gastric cancer in the near future, and a progress has been made in the basic development of next generation onoclytic virotherapy.
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Research Products
(12 results)
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[Journal Article] Inhibition of IL-17A in tumor microenvironment augments cytotoxicity of tumor-infiltrating lymphocytes in tumor-bearing mice2013
Author(s)
Hayata K, Iwahashi M, Ojima T, Katsuda M, Iida T, Nakamori M, Ueda K, Nakamura M, Miyazawa M, Tsuji T, Yamaue H.
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Journal Title
PLoS One
Volume: 8(1)
Pages: e53131
DOI
Peer Reviewed
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[Journal Article] An armed oncolytic herpes simplex virus expressing thrombospondin-1 has an enhanced in vivo antitumor effect against human gastric cancer2013
Author(s)
Tsuji T, Nakamori M, Iwahashi M, Nakamura M, Ojima T, Iida T, Katsuda M, Hayata K, Ino Y, Todo T, Yamaue H.
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Journal Title
Int J Cancer
Volume: 132(2)
Pages: 485-94
Peer Reviewed
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[Journal Article] Lower mediastinal lymph node metastasis is an independent survival factor of Siewert type II and III adenocarcinomas in the gastroesophageal junction2012
Author(s)
Nakamura M, Iwahashi M, Nakamori M, Naka T, Ojima T, Iida T, Katsuda M, Tsuji T, Hayata K, Mastumura S, Yamaue H.
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Journal Title
Am Surg
Volume: 78(5)
Pages: 567-73
Peer Reviewed
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