2014 Fiscal Year Final Research Report
Monitoring of serum Galectin-1 antibodies during perioperative period of patients with gastric cancer
| Project/Area Number |
23591948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
NEMOTO Tetsuo 東邦大学, 医学部, 准教授 (70242203)
NANAMI Tatsuki 東邦大学, 医学部, 助教 (90385831)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | SEREX / serum antibody / malignant tumor |
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| Outline of Final Research Achievements |
Purpose of this study was (i) establish ELISA system to detect serum anti-galectin-1 antibodies, and (ii) evaluate positive rate of serum anti- galectin-1 antibodies in patients with gastric cancer, esophageal cancer and colon cancer. Using a cut-off value of mean +3SD of serum anti- galectin-1 antibody level of healthy controls, positive rate of patients were evaluated. Overall positive rates was 9.7% in gastric cancer, 8% in esophageal cancer, and 8% in colon cancer. No clinicopathological factors were associated with presence of anti- galectin-1 antibodies.
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| Free Research Field |
医歯薬学
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