Targeting therapy of Epithelial-Mesenchymal transition about human gastric cancer.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591949
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hyogo Medical University
• Principal Investigator: SASAKO Mitsuru 兵庫医科大学, 医学部, 教授 (40143490)
• Co-Investigator(Kenkyū-buntansha): KIKUCHI Shojiro 兵庫医科大学, 医学部, 准教授 (70381960)
• Project Period (FY): 2011 – 2013
• Keywords: 線維芽細胞 / 胃がん / 微小環境 / EMT

Research Abstract

We established primary cultured fibroblast library isolated from gastric cancer patients. Fibroblasts modified invasiveness and EMT status of cancer cell. Proteome analysis, RNA microarray indicated over-expression of Ephrin receptor family in cancer stromal cells. Ephrin receptor and related pathway might be good targets of cancer-microenvironment about gastric cancer.

Research Products

• [Journal Article] Overexpression of EphrinA2 receptor in cancer stromal cell is a prognostic factor for the relapse of gastric cancer (2014)
  • Author(s): Shojiro Kikuchi, Nobuaki Kaibe, Koji Morimoto, Hirokazu Fukui, Hirotaka Niwa, Yoshihiro Maeyama, Masashi Takemura, Masaki Matsumoto, Shoji Nakamori, Hiroto Miwa, Seiichi Hirota, Mitsuru Sasako
  • Journal Title: Gastric Cancer Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling (2014)
  • Author(s): Hirokazu Fukui, Xinxing Zhang, Chao Sun, Ken Hara, Shojiro Kikuchi, Takahisa Yamasaki, Takashi Kondo, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Johji Imura, T Fujimori, Mitsuru Sasako, and Hiroto Miwa
  • Journal Title: British Journal of Cancer Volume: Epub ahead of print
  • Peer Reviewed
• [Presentation] がん関連線維芽細胞は胃がん細胞のMMPs発現と浸潤性を増す (2013)
  • Author(s): 菊池正二郎、前山義博、仁和浩貴、瀧井麻美子、海邊展明、山下英孝、大嶋勉、竹村雅至、大津真、笹子三津留
  • Organizer: 日本癌治療学会
  • Place of Presentation: 京都
  • Year and Date: 2013-10-25
• [Presentation] Cancer-fibroblasts mixture was a high risk factor of recurrence in gastric cancer patients (2013)
  • Author(s): 菊池正二郎、前山義博、仁和浩貴、瀧井麻美子、海邊展明、山下英孝、大島勉、竹村雅至、盛本浩二、中森正二、廣田誠一、川口拓之、笹子三津留
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2013-10-03
• [Presentation] がん関連線維芽細胞と胃がんの細胞間相互作用における動態解析 (2013)
  • Author(s): 菊池正二郎、前山義博、仁和浩貴、竹村雅至、堀高明、大嶋勉、松本友寛、海辺展明、山下英孝、笹子三津留
  • Organizer: 日本消化器外科学会
  • Place of Presentation: 宮崎
  • Year and Date: 2013-07-17
• [Presentation] がん関連線維芽細胞は胃がん腹膜播種の悪性度にどのような影響を与えるか? (2013)
  • Author(s): 菊池正二郎、盛本浩二、中森正二、竹村雅至、川崎健太郎、堀高明、大嶋勉、仁和浩貴、松本友寛、海辺展明、山下英孝、廣田誠一、前山義博、笹子三津留
  • Organizer: 日本外科学会
  • Place of Presentation: 福岡
  • Year and Date: 2013-04-11
• [Presentation] がん関連線維芽細胞ががん細胞に与える影響の解析 (2013)
  • Author(s): 前山義博、菊池正二郎、仁和浩貴、笹子三津留
  • Organizer: 日本外科学会
  • Place of Presentation: 福岡
  • Year and Date: 2013-04-11