2013 Fiscal Year Final Research Report
Potential responders to anticancer therapy for colorectal cancer by predictor genes
| Project/Area Number |
23591972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 大腸がん / マイクロアレイ / 薬剤感受性 / 遺伝子プロファイル / 機械学習法 / 個別化医療 |
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| Research Abstract |
To establish the procedures to identify responders to FOLFOX therapy, 83 colorectal cancer (CRC) patients including 42 responders and 41 non-responders were divided into training (54 patients) and test (29 patients) sets. Using Random Forests (RF) algorithm in the training set, predictor genes for FOLFOX therapy were identified, which were applied to test samplesIn the training set, 22 of 27 responders (81.4%) and 23 of 27 non-responders (85.1%) were correctly classified. To improve the prediction model, we removed the outliers determined by RF, and the model could correctly classify 21 of 23 responders (91.3%) and 22 of 23 non-responders (95.6%) in the training set, and 80.0% sensitivity and 92.8% specificity, with an accuracy of 69.2% in 29 independent test samples. RF on gene-expression data for CRC patients was effectively able to stratify responders to FOLFOX therapy, and use of pharmacogenomics in anticancer therapy is the first step in planning personalised therapy.
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Author(s)
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Journal Title
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Author(s)
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[Presentation] Genome-wide analysis of stepwise hepatocarcinogenesis using next generation sequencer2013
Author(s)
Midorikawa Y, Yamamoto S, Ueda H, Sonoda K, Tsuji S, Tatsuno K, Shibata T, Covington K, Morgan M, Wheeler D, Takayama T, Aburatani H.
Organizer
AASLD The Liver Meeting
Place of Presentation
Washington DC
Year and Date
2013-11-02
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[Presentation] Genome-wide analysis of stepwise hepatocarcinogenesis using next generation sequencer2013
Author(s)
Midorikawa Y, Takayama T, Yamamoto S, Ueda H, Sonoda K, Takane K, Tsuji S, Nagae G, Tatsuno K, Morgan M, Wheeler D, Aburatani H.
Organizer
104th, American Association for Cancer Research
Place of Presentation
Washington DC
Year and Date
2013-04-09
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