2013 Fiscal Year Final Research Report
Cryo-therapy was indicated to induce tumor growth inhibition and immune reation
| Project/Area Number |
23591985
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Gifu University |
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Principal Investigator |
OSADA Shinji 岐阜大学, 医学(系)研究科(研究院), 准教授 (80332683)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肝癌 / 抗腫瘍免疫 / 凍結治療 / サイトカイン / 低侵襲治療 / IL-2 / TNF-α / 免疫賦活 |
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| Research Abstract |
In vivo experiments on mouse, the tumor growth was inhibited by cry-ablation treatment from 717.52 to 551.0 on two weeks and from 3147.1 to 2543.1 on four weeks, which compared to control with tumor size (mm3). To demonstrate the relation to immune reaction, IL-2 and TNF-a were evaluated. The n, the expression of IL-2 in the tumor tissue was detected on 12hours after first and second treatment and TNF-a was appeared on 12 hours after first treatment. And the reaction was not shown after third treatment.
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