2013 Fiscal Year Final Research Report

adjuvant immunotherapy using HSP70mRNA encoding dendritic cells after hepatectomy for the patients with hepatocellular carcinoma

Research Project

Project/Area Number	23591988
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	Yamaguchi University
Principal Investigator	TAMESA TAKAO 山口大学, 医学部附属病院, 講師 (30359905)
Project Period (FY)	2011 – 2013
Keywords	肝細胞癌 / 術後補助療法 / 樹状細胞療法
Research Abstract	A Phase 1/2 study of adjuvant immunotherapy using HSP70mRNA encoding dendritic cells after hepatectomy for the patients with hepatocellular carcinoma was performed. Patients were randomly assigned to DC group or surgery group. The safety and the efficacy were evaluated. First 9 patients were recruited to confirm the safety as phase 1 study. (1)Phase 1/2 study: The safety of this therapy was confirmed. All patients (DC group: 18 cases, surgery group: 8 cases) were alive, currently in progress. (2)Immunological assessment :(1)ossibility of non-specific immunoreaction in NK cells and B cells was suggested. (2)Possibility of was specific immunoreaction for HSP70 was suggested by ELISpot assay.

(1 results)