2013 Fiscal Year Final Research Report
Basic and clinical studies regarding to the identification of inflammatory factors promoting the malignant transformation mechanism in digestive organ cancer
| Project/Area Number |
23591992
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
UENO Shinichi 鹿児島大学, 医歯(薬)学総合研究科, 特任教授 (40322317)
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| Co-Investigator(Kenkyū-buntansha) |
NATSUGOE Shoji 鹿児島大学, 大学院医歯学総合研究科, 教授 (70237577)
SAKODA Masahiko 鹿児島大学, 医学部, 助教 (40418851)
ISHIGAMI Sumiya 鹿児島大学, 医学部, 准教 (90325803)
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| Project Period (FY) |
2011 – 2013
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| Keywords | HCC / TAM / TLR-4 / HMGB1 / FrB immunotoxin / ZEB-1 |
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| Research Abstract |
To investigate the cancer transformation of human hepatocellular carcinoma (HCC), the change of HMGB1 and its receptor TLR-4 with tissue macrophage (TAM) were analyzed. Moreover, the usefulness of FrB immunotoxin against TAM was studied if it could diminish tumor's malignant transformation. In HCC, correlations of HMGB1 level and number of TAM, and the number of TAM and patients prognosis were seen. For the knowledge about EMT, transcription factor ZEB-1 participated, too. On the other hand, after giving FrB immunotoxin to nude mouse HepG2 transplant model under skin, a clear effect of tumor promotion was seen. With these considerations, it was suggested that HMGB1 and derived TAM would contribute to the malignant transformation of HCCs, and FrB immunotoxin could be a treatment strategy.
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[Journal Article] Natsugoe S Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC)2013
Author(s)
Hashiguchi M, Ueno S, Sakoda M, Iino S, Hiwatashi K, Minami K, Ando K, Mataki Y, Maemura K, Shinchi H, Ishigami S.
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Journal Title
BMC Cancer
Volume: 13
Pages: 572
DOI
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[Journal Article] Clinical implications of DLL4 expression in gastric cancer2013
Author(s)
Ishigami S, Arigami T, Uenosono Y, Okumura H, Kurahara H, Uchikado Y, Setoyama T, Kita Y, Kijima Y, Nishizono Y, Nakajo A, Owaki T, Ueno S, Natsugoe S.
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Journal Title
J Exp Clin Cancer Res
Volume: 32
Pages: 46
DOI
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[Journal Article] M2-polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancer2013
Author(s)
Kurahara H, Takao S, Maemura K, Mataki Y, Kuwahata T, Maeda K, Sakoda M, Iino S, Ishigami S, Ueno S, Shinchi H, Natsugoe S.
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Journal Title
Pancreas
Volume: 42(1)
Pages: 155-9
DOI
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[Journal Article] Clinicopathological significance of BMP7 expression in esophageal squamous cell carcinoma2012
Author(s)
Megumi K, Ishigami S, Uchikado Y, Kita Y, Okumura H, Matsumoto M, Uenosono Y, Arigami T, Kijima Y, Kitazono M, Shinchi H, Ueno S, Natsugoe S.
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Journal Title
Ann Surg Oncol
Volume: 19(6)
Pages: 2066-71
DOI
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[Journal Article] Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1 and ZEB-2 expression in pancreatic cancer2012
Author(s)
Kurahara H, Takao S, Maemura K, Mataki Y, Kuwahata T, Maeda K, Ding Q, Sakoda M, Iino S, Ishigami S, Ueno S, Shinchi H, Natsugoe S.
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Journal Title
J Surg Oncol
Volume: 105(7)
Pages: 655-61
DOI
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[Presentation] 肝細胞癌(HCC)患者における最近の宿主側・腫瘍側因子の変化と対応2012
Author(s)
安藤慶, 上野真一, 迫田雅彦, 飯野聡, 蔵原弘, 南幸次, 橋口真征, 又木雄弘, 前村公成, 石神純也, 新地洋之, 夏越祥次
Organizer
第112回日本外科学会定期学術集会
Year and Date
20120412-14
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