A Proposal of New Nodal Classification in Gallbladder Cancer

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Niigata University
• Principal Investigator: SAKATA Jun 新潟大学, 医歯学総合病院, 講師 (70447605)
• Co-Investigator(Kenkyū-buntansha): WAKAI Toshifumi 新潟大学, 医歯学系, 教授 (50372470)
• Project Period (FY): 2011 – 2013
• Keywords: 胆嚢癌 / リンパ節転移 / lymph node ratio / リンパ節転移個数

Research Abstract

The aim of this study was to compare the anatomical location of positive nodes, number of positive nodes, and lymph node ratio (LNR) as prognostic predictors in gallbladder cancer. We conducted a retrospective analysis of 135 patients with gallbladder cancer who underwent a radical resection with regional lymphadenectomy.The location of positive nodes was classified according to the AJCC staging manual (7th edition).
Lymph node metastasis was found histologically in 59 (44%) patients. Univariate analysis identified location of positive nodes, number of positive nodes, and LNR as significant prognostic factors. Multivariate analysis identified number of positive nodes as an independent prognostic factor (P = 0.004); however, location of positive nodes and LNR failed to remain as an
independent variable.The number of positive lymph nodes better predicts patient outcome after resection than either the location of positive lymph nodes or LNR in patients with gallbladder cancer.

Research Products

• [Journal Article] Assessment of lymph node status in gallbladder cancer : location, number, or ratio of positive nodes (2012)
  • Author(s): Shirai Y, Sakata J, Wakai T, Ohashi T, Ajioka Y, Hatakeyama K.
  • Journal Title: World J Surg Oncol Volume: 10 Pages: 87
  • Peer Reviewed
• [Journal Article] Regional lymphadenectomy for gallbladder cancer : rational extent, technical details, and patient outcomes (2012)
  • Author(s): Shirai Y, Wakai T, Sakata J, Hatakeyama K.
  • Journal Title: World J Gastroenterol Volume: 18 Pages: 2775-83
  • Peer Reviewed
• [Journal Article] Full-thickness cholecystectomy with limited lymphadenectomy for gallbladder cancer (2012)
  • Author(s): Shirai Y, Sakata J, Wakai T, Hatakeyama K.
  • Journal Title: Hepatogastroenterology Volume: 59 Pages: 1338-40
  • Peer Reviewed
• [Journal Article] Extended radical cholecystectomy for gallbladder cancer : long-term outcomes, indications and limitations (2012)
  • Author(s): Shirai Y, Sakata J, Wakai T, Ohashi T, Hatakeyama K.
  • Journal Title: World J Gastroenterol Volume: 18 Pages: 4736-43
  • Peer Reviewed
• [Presentation] Regional lymphadenectomy for gallbladder cancer : rational extent and patient outcomes (2014)
  • Author(s): Sakata J, Wakai T, Hirose Y, Katada T, Sudo N, Ohashi T, Takizawa K, Takano K, Kobayashi T, Minagawa M.
  • Organizer: IHPBA World Congress 2014
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-03-25
• [Presentation] "Extended" radical cholecystectomy for gallbladder cancer (2014)
  • Author(s): Sakata J, Wakai T, Hirose Y, Katada T, Sudo N, Ohashi T, Takizawa K, Takano K, Kobayashi T, Minagawa M.
  • Organizer: IHPBA World Congress 2014
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-03-25
• [Presentation] Assessment of lymph node status in gallbladder cancer : location, number, or ratio of positive nodes (2013)
  • Author(s): Sakata J, Ohashi T, Hirose Y, Takizawa K, Takano K, Kobayashi T, Minagawa M, Wakai T.
  • Organizer: International Surgical Week 2013
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 20130825-29