2013 Fiscal Year Final Research Report
Investigation into epigenetic regulatory mechanism by microRNA in carcinogenesis
| Project/Area Number |
23592015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
TAKAMORI Hiroshi 熊本大学, 医学部附属病院, 非常勤診療医師 (90363514)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAHARA Osamu 熊本大学, 医学部附属病院, 非常勤診療医師 (40583042)
OHMURAYA Masaki 熊本大学, 大学院先導機構, 特任助教 (60398229)
SAKAMOTO Yasuo 熊本大学, 医学部附属病院, 特任助教 (00452897)
HORINO Kei 熊本大学, 医学部附属病院, 非常勤診療医師 (60452900)
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| Project Period (FY) |
2011 – 2013
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| Keywords | IPMN / エピジェネティクス / EZH2 / Ki67 / p27Kip1 / miR-101 |
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| Research Abstract |
EZH2 is associated with the accelerated cell proliferation in pancreatic IPMN via the downregulation of p27Kip1 by analyzing surgically resected pancreatic IPMN. On the other hand, Transfection of pre-miR-101 into pancreatic cell line decreased EZH2 expression in mRNA and protein level. Expression of miR-101 was significantly lower in malignant IPMN than benign IPMN. These result shows miR-101 regulate EZH2 expression in pancreatic IPMN.
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[Journal Article] Portal vein embolization can prevent intrahepatic metastases to non-embolized liver2012
Author(s)
Okabe K, Beppu T, Masuda T, Hayashi H, Okabe H, Komori H, Horino K, Sugiyama S, Ishiko T, Takamori H, Yamanaka T, Baba H.
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Journal Title
Hepatogastroenterology
Volume: 59(114)
Pages: 538-41
DOI
Peer Reviewed
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[Journal Article] Liver hanging maneuver decreases blood loss and operative time in a right-side hepatectomy2012
Author(s)
Beppu T, Ishiko T, Chikamoto A, Komori H, Masuda T, Hayashi H, Okabe H, Otao R, Sugiyama S, Nasu J, Horino K, Takamori H, Baba H.
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Journal Title
Hepatogastroenterology
Volume: 59(114)
Pages: 542-5
DOI
Peer Reviewed
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[Journal Article] The expression levels of CD44v6 are correlated with the invasiveness of hepatocellular carcinoma in vitro, but do not appear to be clinically significant2012
Author(s)
Mima K, Okabe H, Ishimoto T, Hayashi H, Nakagawa S, Kuroki H, Miyake K, Takamori H, Beppu T, Baba H.
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Journal Title
Oncol Lett.
Volume: 3(5)
Pages: 1047-1051
DOI
Peer Reviewed
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[Journal Article] A nomogram predicting disease-free survival in patients with colorectal liver metastases treated with hepatic resection : multicenter data collection as a Project Study for Hepatic Surgery of the Japanese Society of Hepato-Biliary- Pancreatic Surgery2012
Author(s)
Beppu T, Sakamoto Y, Hasegawa K, Honda G, Tanaka K, Kotera Y, Nitta H, Yoshidome H, Hatano E, Ueno M, Takamura H, Baba H, Kosuge T, Kokudo N, Takahashi K, Endo I, Wakabayashi G, Miyazaki M, Uemoto S, Ohta T, Kikuchi K, Yamaue H, Yamamoto M, Takada T.
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Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 19(1)
Pages: 72-84
DOI
Peer Reviewed
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[Journal Article] Pyrosequencing assay to measure LINE-1 methylation level in esophageal squamous cell carcinoma2012
Author(s)
Iwagami S, Baba Y, Watanabe M, Shigaki H, Miyake K, Ida S, Nagai Y, Ishimoto T, Iwatsuki M, Sakamoto Y, Miyamoto Y, Baba H.
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Journal Title
Ann Surg Oncol
Volume: 19(8)
Pages: 2726-32
DOI
Peer Reviewed
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[Journal Article] Safe laparoscopic resection of a gastric gastrointestinal stromal tumor close to the esophagogastric junction2012
Author(s)
Sakamoto Y, Sakaguchi Y, Akimoto H, Chinen Y, Kojo M, Sugiyama M, Morita K, Saeki H, Minami K, Soejima Y, Toh Y, Okamura T.
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Journal Title
Surg Today
Volume: 42(7)
Pages: 708-11
DOI
Peer Reviewed
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[Journal Article] Primary malignant melanoma of the esophagus with extensive intraepithelial extension2012
Author(s)
Inadomi K, Ishimoto T, Watanabe M, Iwatsuki M, Arima K, Ida S, Nagai Y, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Honda Y, Iyama K, Baba H.
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Journal Title
Ann Thorac Surg
Volume: 94(6)
Pages: 2105-7
DOI
Peer Reviewed
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[Journal Article] Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system2011
Author(s)
Beppu T, Hayashi H, Okabe H, Masuda T, Mima K, Otao R, Chikamoto A, Doi K, Ishiko T, Takamori H, Yoshida M, Shiraishi S, Yamashita Y, Baba H.
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Journal Title
J Gastroenterol
Volume: 46(7)
Pages: 938-43
DOI
Peer Reviewed
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[Journal Article] Laparoscopy-assisted resection of an undiagnosed liver tumor and ascending colon cancer via mini median laparotomy : report of a case2011
Author(s)
Mima K, Beppu T, Chikamoto A, Ishiko T, Horino K, Hayashi N, Watanabe M, Takamori H, Okabe K, Yamanaka T, Baba H.
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Journal Title
Surg Today
Volume: 41(12)
Pages: 1633-8
DOI
Peer Reviewed
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[Journal Article] Primary neuroendocrine tumor in the liver treated by hepatectomy. Primary neuroendocrine tumor in the liver treated by hepatectomy : report of a case2011
Author(s)
Mima K, Beppu T, Murata A, Otao R, Miyake K, Okabe H, Masuda T, Okabe K, Sugiyama S, Chikamoto A, Ishiko T, Takamori H, Baba H.
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Journal Title
Surg Today
Volume: 41(12)
Pages: 1655-60
DOI
Peer Reviewed
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[Journal Article] Pigmented hepatocellular adenoma : report of a case2011
Author(s)
Masuda T, Beppu T, Ikeda K, Ishiko T, Chikamoto A, Hayashi H, Okabe H, Otao R, Takamori H, Namimoto T, Iyama K, Baba H.
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Journal Title
Surg Today
Volume: 41(6)
Pages: 881-3
DOI
Peer Reviewed
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