2013 Fiscal Year Final Research Report
Innovation of novel therapeutic approach to pancreatic cancer using galectin-3 and AMF
| Project/Area Number |
23592017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
SHIMURA Tatsuo 福島県立医科大学, 医学部, 准教授 (00282393)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Masahiko 福島県立医科大学, 医学部, 教授 (10226178)
TAKENOSHITA Seiichi 福島県立医科大学, 医学部, 教授 (10167489)
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| Project Period (FY) |
2011 – 2013
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| Keywords | galectin-3 / 膵癌 / ＡＭＦ |
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| Research Abstract |
Galectin-3 (Gal-3) is beta-galactoside-binding protein, having binding capacity with glycoprotein and glycolipid on a cell surface. Gal-3 engages in cell differentiation, organ formation, tumor progression, apoptosis and so on, however, precise mechanisms of them have not yet been clarified.
We investigated the relationship between Gal-3 and pancreatic cancer, especially on cell proliferation, migration and invasion using pancreatic cancer cell lines. We also analyzed changes of tolerance toward anti-cancer drugs when expression level of Gal-3 was inhibited in the cell lines. Inhibition of Gal-3 expression led to inhibition of migration and invasion of the cells. It also augmented their susceptibility to anti-cancer agents, like gemcitabine and cisplatinum.
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[Journal Article] Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression invoving MDSCs and systemic inflammation in patients with cancer of the digestive system2013
Author(s)
Nakamura I, Shibata M, Gonda K, Yazawa T, Shimura T, Anazawa T, Suzuki S, Sakurai K, Koyama Y, Ohto H, Tomita R, Gotoh M, Takenoshita S.
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Journal Title
Oncology Letters
Volume: 5巻
Pages: 1682-1688
URL
Peer Reviewed
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[Journal Article] Increased IL-17 production correlates with immunosuppression involving myeloid-derived suppressor cells and nutritional impairment in patients with various gastrointestinal cancers2013
Author(s)
Yazawa T, Shibata M, Gonda K, Machida T, Suzuki S, Kenjo A, Nakamura I, Tsuchiya T, Koyama Y, Sakurai K, Shimura T, Tomita R, Ohto H, Gotoh M, Takenoshita S.
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Journal Title
Mol Clin Oncol
Volume: 1巻
Pages: 675-679
URL
Peer Reviewed
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[Journal Article] Circuating myeloid-derived suppressor cells are increased and correlate to immune suppression, inflammation and hypoproteinemia in patients with cancer2012
Author(s)
Ohki S, Shibata M, Gonda K, Machida T, Shimura T, Nakamura I, Ohtake T, Koyama Y, Suzuki S, Ohto H, Takenoshita S.
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Journal Title
Oncology Report
Volume: 28巻
Pages: 453-458
DOI
Peer Reviewed
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[Journal Article] Clinical evaluation of dedritic cells vaccination for advanced cancer patients at Fukushima Medical University2012
Author(s)
Nakamura I, Kanazawa M, Sato Y, Irisawa A, Takagi T, Ogata T, Kashimura S, Kenjo A, Suzuki H, Shibata M, Shimura T, Ohira H, Goto M, Takenoshita S, Ohto H.
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Journal Title
Fukushima J Med Sci.
Volume: 58巻
Pages: 40-48
URL
Peer Reviewed
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