2013 Fiscal Year Final Research Report
Study of myocardial protection by sympathetic nerve stimulation using a new SPY-Q system myocardial blood flow evaluation
| Project/Area Number |
23592031
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Go 金沢大学, 医学系, 教授 (60242492)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 交感神経刺激 / 高周波刺激 / 心筋酸素代謝 / 心筋保護法 / Ganglion Plexus |
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| Research Abstract |
The purpose of this study is to obtain safety cardiac arrest by sustained stimulation of bilateral sympathetic nerve and Ganglion Plexus. Using a pen type bipolar stimulation device (25-30 Hz, rectangular bipolar pulse, output 8 V, pulse width 0.4 ms) with distance between electrodes 3 mm, a stable cardiac arrest was obtained during 30 minutes. During stimulation (30 minutes), cardiac arrest was obtained and after stopping stimulation, heart beating was started immediately. Heart rate and systemic blood pressure were recovered to the controlled value in about 10 minutes. During cardiac arrest, myocardial blood flow and myocardial oxygen saturation were not decreased. The new cardiac protection of the sympathetic nerve stimulation resulted in safe and useful methods without decreasing of cardiac dysfunction and myocardial oxygen metabolism.
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