2013 Fiscal Year Final Research Report
Bone Marrow Mononuclear Cell transplantation as a therapeutic option for pulmonary arterial hypertension and its role of BM-MNCs
| Project/Area Number |
23592040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Tetsuya 徳島大学, ヘルスバイオサイエンス研究部, 教授 (80240886)
SUGANO Mikio 徳島大学, 大学病院, 医員 (70563807)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肺高血圧 / 骨髄単核球移植 / マウスモデル |
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| Research Abstract |
We investigated the effects and possible mechanism of bone marrow mononuclear cell (BM-MNC) transplantation on pulmonary arterial hypertension induced by monocrotaline. The monocrotaline-injected mice improved significantly 4 weeks after BM-MNC transplantation compared with mice at 8 weeks after monocrotaline injection. BM-MNCs were incorporated into the lung at 30 minutes after transplantation, and significant vascular endothelial growth factor (VEGF) upregulation and almost no change of its receptor expression were observed in the lung tissue 1 week after transplantation. Moreover the improvement of pulmonary arterial hypertension was inhibited by simultaneous administration of VEGF receptor-2 inhibitor with BMMNC transplantation.
BMMNC transplantation improves monocrotaline-induced pulmonary arterial hypertension by favorable pulmonary artery remodeling through VEGF upregulation and its receptor system.
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