2013 Fiscal Year Final Research Report
The evaluation of scaffold-free 3-D cardiac graft effect on heart failure model
| Project/Area Number |
23592044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Saga University |
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Principal Investigator |
NOGUCHI Ryo 佐賀大学, 医学部, 助教 (70530187)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Shigeki 佐賀大学, 医学部, 教授 (70243938)
NODE Kouichi 佐賀大学, 医学部, 教授 (80359950)
NAKAYAMA Kouichi 佐賀大学, 工学系研究科, 教授 (50420609)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 心筋再生 / 再生医療 / 組織工学 |
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| Research Abstract |
In this study, we developed completely scaffold-free 3-dimensinal contractile cardiac grafts using spheroids and its self-organize characteristic. We could succeeded in fabricate cardiac graft with maximum diameter 1cm. The cardiac graft were graftted on nude rat heart, we could confirm the graft were biable in histological analysis. Furthermore, in the animal implantation study on AMI model, effectiveness of these grafts for AMI was confirmed. We consider that applying our scaffold free three dimensional tissue engineering technology to cardiac regeneration therapy is feasible. We expect that this technology will become a promising tool to treat end-stage heart failure.
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