Clinical analysis of the responsibility gene in the aortic aneurysm outbreak aiming at an early operation and the prevention

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yokohama City University
• Principal Investigator: MASUDA MUNETAKA 横浜市立大学, 医学(系)研究科(研究院), 教授 (10190365)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Naomichi 横浜市立大学, 医学研究科, 教授 (80325638) ; SUZUKI Shinichi 横浜市立大学, 医学部, 准教授 (90285130) ; IMOTO Kiyotaka 横浜市立大学, 市民総合医療センター, 教授 (40203335) ; UCHIDA Keiji 横浜市立大学, 市民総合医療センター, 准教授 (50275062)
• Project Period (FY): 2011 – 2013
• Keywords: 責任遺伝子 / 大動脈瘤発生 / 早期手術及び予防

Research Abstract

This study analyzes the abnormality of the responsibility gene cluster of the Mendel hereditary disease to bring about a dissociative aortic aneurysm and a genuine aortic aneurysm with high probability and is intended that I clarify a genotype and the love poem of clinical manifestations (canceration, dissociation and cancer explosion). Using this love poem, I switch it to the custom tailoring treatment that they put together in the risk that the genotype of individual cases shows the decision of the treatment policy to, and I establish the adaptation of the operation in the early stage that is low aggressions such as the stent graft interpolation art, and the death rate is high, and medical expenses aim at the evasion of the large amount of emergency surgery. In addition, I examine the clinical effects such as angiotensin receptor repressors and am intended to contribute to medical expenses reduction.

Research Products

• [Journal Article] Mid-Term Outcomes of Acute Type B Aortic Dissection in Japan Single Center (2013)
  • Author(s): Minami T, Imoto K, Uchida K, Yasuda S, Karube N, Suzuki S, Masuda M.
  • Journal Title: Annals Thorac Cardiovasc Surgery Volume: 19 Pages: 461-467
  • Peer Reviewed
• [Journal Article] Successful endovascular treatment of a ruptured superior mesenteric artery in a patient with Ehlers‒Danlos syndrome (2013)
  • Author(s): Yasuda S, Imoto K, Uchida K, Machida D, Yanagi H, Sugiura T, Kurosawa K, Masuda M.
  • Journal Title: Annals of Vascular Surgery Volume: 27(7) Pages: 975
  • Peer Reviewed
• [Journal Article] Intramural haematoma should be referred to as thrombosed-type aortic dissection (2013)
  • Author(s): Uchida K, Imoto K, Karube N, Minami T, Cho T, Goda M, Suzuki S, Masuda M.
  • Journal Title: European Journal of Cardio-Thoracic Surgery Volume: 44(2) Pages: 366-369
  • Peer Reviewed
• [Journal Article] Clinical outcomes of emergency surgery for acute type B aortic dissection with rupture (2013)
  • Author(s): Minami T, Imoto K, Uchida K, Yasuda S, Sugiura T, Karube N, Suzuki S, Masuda M.
  • Journal Title: European Journal of Cardio-Thoracic Surgery Volume: 44 Pages: 360-365
  • Peer Reviewed
• [Journal Article] Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods : resequencing microarray technology and next-generation sequencing (2012)
  • Author(s): Sakai H, Suzuki S, Mizuguchi T, Imoto K, Yamashita Y, Doi H, Kikuchi M, Tsurusaki Y, Saitsu H, Miyake N, Masuda M, Matsumoto N.
  • Journal Title: Human Genetics Volume: 131(4) Pages: 591-599
  • Peer Reviewed
• [Presentation] Acute aortic dissection in Asian versus Western patients:Differences in patients presentation (2013)
  • Author(s): Meuris B,Goda M,Minami T,Imoto K,Masuda M.
  • Organizer: The society for heart valve disease/Heart valve society of America 7th Biennial Congress
  • Place of Presentation: Venice,Italy
  • Year and Date: 20130622-25
• [Presentation] Evaluation of false lumen during chronic phase in Stanford type B thrombosed-type aortic dissection (2013)
  • Author(s): Cho T, Imoto K, Uchida K, Karube N, Yasutsune T, Umeda E, Goda M, Yabu N, Masuda M.
  • Organizer: The 8th Korea-Japan joint meeting of vascular surgery
  • Place of Presentation: Seol, Korea
  • Year and Date: 20130425-27
• [Presentation] Acute aortic dissection-Western Europe vs Japan- (2013)
  • Author(s): Goda M,Minami T,Imoto K,Kakazu A,Fujikawa Y,Katayama Y,Isomatsu Y,Suzuki S,Masuda M,Meuris B.
  • Organizer: The 21st Annual Meeting of The Asian Society for Cardiovascular and Thoracic Surgery
  • Place of Presentation: Kobe
  • Year and Date: 20130404-07
• [Presentation] GENE ANALYSIS IN PATIENTS WITH NON-SYNDROMIC AORTIC ANEURYSM AND DISSECTION (2013)
  • Author(s): Suzuki S, Masuda M, Goda M, Katayama Y, Sakai A, Matsumoto N.
  • Organizer: The Houston Aortic Symposium : Frontiers in Cardiovascular Diseases, the Sixth in the Series
  • Place of Presentation: Houston, USA
  • Year and Date: 20130321-23