Spirometric and radiological evaluation of the remnant lung long after major pulmonary resection: can compensatory phenomena be recognized in clinical cases?

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Chiba University
• Principal Investigator: MIZOBUCHI TERUAKI 千葉大学, 医学部附属病院, 講師 (50569861)
• Co-Investigator(Kenkyū-buntansha): YOSHINO Ichiro 千葉大学, 大学院医学研究院, 教授 (40281547) ; YOSHIDA Shigetoshi 千葉大学, 大学院医学研究院, 准教授 (90334200) ; SAKAIRI Yuichi 千葉県がんセンター, 医員 (30551949) ; IWATA Takekazu 千葉大学, 医学部附属病院, 助教 (30586681) ; TAGAWA Tetsuzo 千葉大学, 大学院医学研究院, 助教 (90419557) ; SUZUKI Hidemi 千葉大学, 医学部附属病院, 助教 (60422226)
• Project Period (FY): 2011 – 2013
• Keywords: 呼吸器外科学 / 代償性肺成長 / 肺再生 / 肺切除 / 仮想肺組織量

Research Abstract

It has been generally accepted that lungs cannot regenerate in mature human. After a major lung resection, however, mechanical stretch, shear stress, and a variety of growth factors are induced in the remnant lung, and those are known to be driving forces for compensatory lung growth in animal models. Radiologically estimated "Lung Weight" is focused on as a significant parameter to determine severity of ARDS that is calculated by lung volume and density. Therefore, we also utilized the concept of radiologic estimation of lung weight for evaluation of the compensation. Before clinical investigation, a rational of radiologic lung weight was validated in healthy volunteers. This result met our hypothesis that radiologic lung weight is constant at any respiratory phase. Hypertrophic change of the remnant lung was recognized in living lung donors and lung cancer patients who underwent more than a 10-subsegment resection.

Research Products

• [Journal Article] Spirometric and radiological evaluation of the remnant lung long after major pulmonary resection : can compensatory phenomena be recognized in clinical cases? (2013)
  • Author(s): Mizobuchi T, Wada H, Sakairi Y, Suzuki H, Nakajima T, Tagawa T, Iwata T, Motoori K, Yoshida S, Yoshino I
  • Journal Title: Surg Today Volume: 27
  • Peer Reviewed
• [Journal Article] Radiologic evaluation for volume and weight of remnant lung in living lung donors (2013)
  • Author(s): Mizobuchi T, Chen F, Yoshino I, Iwata T, Yoshida S, Bando T, Date H
  • Journal Title: J Thorac Cardiovasc Surg Volume: 146巻 Pages: 1253-8
• [Journal Article] 慢性閉塞性肺疾患症例における"仮想肺組織量"を指標とした、肺切除後のいわゆる"代償性肺成長"の評価 (2012)
  • Author(s): 溝渕輝明、吉田成利、稲毛輝長、森本淳一、坂入祐一、石橋史博、米谷卓郎、岩田剛和、千代雅子、守屋康充、星野英久、吉野一郎
  • Journal Title: 臨床呼吸生理 Volume: 44巻 Pages: 33-37
• [Presentation] Radiologic evaluation for volume and weight of remnant lung in living lung donors (2013)
  • Author(s): Teruaki Mizobuchi, Fengshi Chen, Takekazu Iwata, Masaaki Sato, Akihiro Aoyama, Toru Bando, Yuichi Sakairi, Yoshito Yamada, Shigetoshi Yoshida, Hiroshi Date, Ichiro Yoshino
  • Organizer: International Society for Heart and Lung Transplantation
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20130424-27
• [Presentation] 臨床例における肺切除後の機能と形態に関する研究 (2012)
  • Author(s): 溝渕輝明,陳豊史,岩田剛和,佐藤雅昭,青山晃博,坂入祐一,鈴木秀海,山田義人,田川哲三,千代雅子,吉田成利,板東徹,伊達洋至,吉野一郎
  • Organizer: 第65回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡国際会議場・福岡サンパレスホテル&ホール
  • Year and Date: 20121017-20
• [Presentation] COPD症例は、肺切除後の"代償性肺成長"を示さない:"仮想肺組織量"を指標とした検証 (2012)
  • Author(s): 溝渕輝明、吉田成利、稲毛輝長、森本淳一、坂入祐一、石橋史博、千代雅子、米谷卓郎、岩田剛和、守屋康充、星野英久、吉野一郎
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉市幕張メッセ
  • Year and Date: 20120412-14