2013 Fiscal Year Final Research Report
Pre-clinical study on pulmonary perfusion preservation using modified ET-Kyoto solutions
Project/Area Number |
23592056
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Thoracic surgery
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Research Institution | Kyoto University |
Principal Investigator |
BANDO TORU 京都大学, 医学(系)研究科(研究院), 准教授 (20293954)
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Co-Investigator(Kenkyū-buntansha) |
DATE Hiroshi 京都大学, 大学院医学研究科, 教授 (60252962)
AOYAMA Akihiro 京都大学, 大学院医学研究科, 助教 (60379047)
SATO Masaaki 京都大学, 大学院医学研究科, 助教 (00623109)
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Project Period (FY) |
2011 – 2013
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Keywords | 呼吸器外科 / 移植・再生医療 / トランスレーショナルリサーチ |
Research Abstract |
We evaluated the effects of continuous perfusion on pulmonary preservation using a rat and a dog ex vivo perfusion models aiming at clinical application of modified ET-K solution as a perfusate. Neither a potassium-reduced ET-K nor an ET-K without HES demonstrated sufficient pulmonary preservation for reliable clinical practice. In addition, supplementation with red blood cells to the perfusion solution also failed to show any significant improvements of the preservation effect. A further extensive modification is needed for the clinical application.
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[Journal Article] Protective effect of plasmin in marginal donor lungs in an ex vivo lung perfusion model2013
Author(s)
Motoyama H, Chen F, Ohsumi A, Hijiya K, Okita K, Nakajima D, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
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Journal Title
J Heart Lung Transplant
Volume: 32
Pages: 505-510
Peer Reviewed
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[Journal Article] Reconditioning of lungs donated after cardiac death using short-term hypothermic machine perfusion2012
Author(s)
Nakajima D, Chen F, Okita K, Motoyama H, Hijiya K, Ohsumi A, Sakamoto J, Yamada T, Sato M, Aoyama A, Bando T, Date H
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Journal Title
Transplantation
Volume: 94
Pages: 999-1004
Peer Reviewed
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[Journal Article] Protective effect of pre-recovery surfactant inhalation on lungs donated after cardiac death in a canine lung transplantation model2012
Author(s)
Ohsumi A, Chen F, Sakamoto J, Nakajima D, Hijiya K, Motoyama H, Okita K, Kikuchi R, Yamada T, Bando T, Date H
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Journal Title
J Heart Lung Transplant
Volume: 31
Pages: 1136-1142
Peer Reviewed
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[Journal Article] Effects of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model2011
Author(s)
Sakamoto J, Chen F, Yamada T, Nakajima D, Ohsumi A, Kikuchi R, Zhao X, Fujinaga T, Shoji T, Sakai H, Bando T, Date H
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Journal Title
Transplantation
Volume: 92
Pages: 864-870
Peer Reviewed
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[Presentation] Protective effect of beta-2 adrenoreceptor agonist inhalation during ex vivo lung perfusion2013
Author(s)
Kondo T, Chen F, Ohsumi A, Hijiya K, Motoyama H, Yamada T, Sato M, Aoyama A, Bando T, Date H
Organizer
The 13th Congress of the Asian Society of Transplantation
Place of Presentation
Kyoto, Japan
Year and Date
2013-09-04
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[Presentation] Protective effect of plasmin in marginal donor lungs in an ex vivo lung perfusion model2013
Author(s)
Motoyama H, Chen F, Ohsumi A, Hijiya K, Okita K, Kondo T, Nakajima D, Sakamoto J, Yamada T, Aoyama A, Sato M, Bando T, Date H
Organizer
The 33rd Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
Montral, Quebec, Canada
Year and Date
2013-04-26
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[Presentation] Hypothermic machine perfusion for lung preservation : technical development in a canine model2012
Author(s)
Nakajima D, Chen F, Okita K, Motoyama H, Hijiya K, Ohsumi A, Sakamoto J, Yamada T, Sato M, Aoyama A, Sakai H, Bando T, Date H
Organizer
The 32nd Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
Prague, Czech Republic
Year and Date
2012-04-18
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[Presentation] Reconditioning of lungs from non-heart-beating donors with normothermic ex vivo lung perfusion2012
Author(s)
Nakajima D, Yamada T, Chen F, Sakamoto J, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H
Organizer
The 31st Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
San Diego, USA
Year and Date
2012-04-16
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[Presentation] Hypothermic ex vivo perfusion prevents ischemia reperfusion injury in rat lungs from non-heart-beating donors2012
Author(s)
Nakajima D, Yamada T, Chen F, Sakamoto J, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H
Organizer
The 31st Annual Meeting of the International Society for Heart and Lung Transplantation
Place of Presentation
San Diego, USA
Year and Date
2012-04-15
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[Presentation] Protective effect of ventilation before organ procurement on graft lungs donated after cardiac death in a canine lung transplantation model2012
Author(s)
Sakamoto J, Yamada T, Chen F, Nakajima D, Ohsumi A, Fujinaga T, Shoji T, Sakai H, Bando T, Date H
Organizer
The 31st Annual Meeting of the International Heart and Lung Transplantation
Place of Presentation
San Diego, USA
Year and Date
2012-04-14
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