2013 Fiscal Year Final Research Report
Non-invasive assessment for acute rejection in lung transplantation.
| Project/Area Number |
23592057
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SAKAI HIROAKI 京都大学, 医学(系)研究科(研究院), その他 (50362489)
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| Co-Investigator(Kenkyū-buntansha) |
DATE Hiroshi 京都大学, 医学研究科, 教授 (60252962)
SHOJI Tuyoshi 公益財団法人田附興風会, 呼吸器外科, 研 究員 (80402840)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 強制オッシレーション法 / 急性肺拒絶評価 / 肺インピーダンス / tissue fraction |
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| Research Abstract |
After lung transplantation, early detection of acute rejection is important for timely and optimal treatment. We examined the relationship between lung mechanics and rejection grade in a rat acute rejection model using the forced oscillation technique (FOT), which provides non-invasive assessment of lung function. We assessed lung resistance and elastance (RL and EL) from implanted left lung of these animals. The rejection severity grade (A-grade) was quantified from histological images using tissue fraction (TF: tissue + cell infiltration area / total area). We found that TF, RL and EL worsened according to A-grade. Both Elow (at lowest frequency of EL) and Ehet (the absolute difference between Elow and maximum value of EL) showed correlation with the mean value of TF. Our results suggest that the dynamic elastance as well as its frequency dependence reflect A-grade. These indexes should prove useful for detecting and monitoring the progression disease in acute rejection.
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Research Products
(40 results)
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[Journal Article] A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japnese population2012
Author(s)
Kinose D, Ogawa E, Hirota T, Ito I, Kubo M, Haruna A, Marumo S, Hoshino Y, Muro S, Hirai T, Sakai H, Date H, Tamari M, Miyoshi M
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Journal Title
Respirology
Volume: 17(1)
Pages: 164-71
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[Journal Article] Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma2012
Author(s)
Ishikawa M, Miyahara R, Sonobe M, Horiuchi M, Mennju T, Nakayama E, Kobayashi M, Kikuchi R, Kitamura J, Imamura N, Huang CL, Date H
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Journal Title
Lung Cancer
Volume: 76(3)
Pages: 431-8
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[Journal Article] Short-term outcome in living donors for lung transplantation : the role of preoperative computer tomographic evaluations of fissures and vascular anatomy2012
Author(s)
Chen F, Fujinaga T, Shoji T, Kubo T, Sonobe M, Sato M, Aoyama A, Sato T, Sakai H, Bando T, Date H
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Journal Title
Transplant Int
Volume: 25(7)
Pages: 732-8
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[Journal Article] Oxidative stress induced interleukin-32 mRNA expression in human bronchial epitherial cells2012
Author(s)
Kudo M, Ogawa E, Kinose D, Haruna A, Takahashi T, Tahabe N, Marumo S, Hoshino Y, Hirai T, Sakai H, Muro S, Date H, Mishima M
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Journal Title
Respir Res
Volume: 13
Pages: 19
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[Journal Article] Protective effect of pre-recovery surfactant inhalation on lungs donated after cardiac death in a canine lung transplantation model2012
Author(s)
Osumi A, Chen F, Sakamoto J, Nakajima D, Hijiya K, Motoyama H, Okita K, Horita K, Kikuchi R, Yamada T, Bando T, Date H
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Journal Title
J Heart Lung Transplant
Volume: 31(10)
Pages: 1136-42
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[Journal Article] Effect of preprocurement ventilation on lungs donated after cardiac death in a canine lung transplantation model2011
Author(s)
Sakamoto J, Chen F, Yamada T, Nakajima D, Ohsumi A, Kikuchi R, Zhao X, Fujinaga T, Shoji T, Sakai H, Bando T, Date H
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Journal Title
Transplantation
Volume: 92(8)
Pages: 864-70
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