Mechanism and inhibition of ischemia reperfusion injury after lung transplantation from donation after cardiac death

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592063
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Ehime University
• Principal Investigator: OKAZAKI MIKIO 愛媛大学, 医学部附属病院, 講師 (50467750)
• Co-Investigator(Kenkyū-buntansha): SANO Yoshifumi 愛媛大学, 大学院医学系研究科, 准教授 (60322228) ; YAMANE Masaomi 岡山大学, 医学部附属病院, 助教 (20432643)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 肺移植 / 虚血再灌流障害 / 心停止ドナー

Outline of Final Research Achievements

Although lung transplantation from donation after cardiac death (DCD), is limited by warm ischemic periods, the molecular mechanism of warm ischemia-reperfusion-injury (IRI) has not been well elucidated. The purpose of this study was to clarify the particular longitudinal mechanisms of molecular factors involved in warm IRI. This study indicates that anti-inflammatory pathways may play important roles in the graft recovery after lung transplantation from DCD.

Free Research Field

肺移植