2013 Fiscal Year Final Research Report

Establishment of therapeutic strategy for synchronous double lung cancers based on molecular analysis

Research Project

Project/Area Number	23592068
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Thoracic surgery
Research Institution	Nagasaki University
Principal Investigator	NAGAYASU Takeshi 長崎大学, 医歯(薬)学総合研究科, 教授 (80284686)
Co-Investigator(Kenkyū-buntansha)	YAMASAKI Naoya 長崎大学, 准教授 (70404217) TSUCHIYA Tomoshi 長崎大学, 大学院医歯薬学総合研究科, 講師 (30437884) MIYAZAKI Takuro 長崎大学病院, 助教 (00584749)
Project Period (FY)	2011 – 2013
Keywords	同時多発肺癌 / 肺内転移 / 原発多発肺癌 / 染色体構造変化 / array CGH
Research Abstract	We performed molecular analysis of 12 synchronous double lung cancer patients without lymph node metastasis (intrapulmonary metastasis in the same lobe (pm1): n=6, primary: n=6). We then evaluated the clinical outcomes of patients with pathologically diagnosed synchronous double lung cancers (intrapulmonary metastasis (pm): n=80, primary: n=39) and other T3 tumors (n=230). Examination of the concordance rate (CR) of the copy number changes (CNCs) for paired tumors showed that the metastasis group was larger than the primary group (55.5% vs. 19.6%, p=0.04). Pathological diagnosis and molecular classification were the same in 10 out of 12 cases (83%). Both pathological and molecular assessment using aCGH adapted in the current study appeared to have a consistency.

(2 results)