2013 Fiscal Year Final Research Report
Clinical Significance of Regulatory T Cells in Regional Lymph Node Lymphocytes of Non-Small-Cell Lung Cancer and overcoming immune-escape mechanism
| Project/Area Number |
23592079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肺癌 / 制御性T細胞 / 腫瘍免疫 / 免疫逃避 / 細胞障害性T細胞 |
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| Research Abstract |
Regulatory T cells (Tregs) are potent immunosuppressive cells that play a crucial role in tumor immune escape. The purpose of the present study was to evaluate the prognostic significance of CD4+ CD25+ Foxp3+ Tregs in the regional lymph node lymphocytes (RLNL) in patients who underwent surgical resection of non-small cell lung cancer (NSCLC). The proportions of Tregs in the RLNL were determined by flow cytometry and quantitative RT–PCR. The 5-year survival rate was significantly better in patients with the lower proportion of Tregs than that in the higher patients. The higher proportion of Tregs in the RLNL was a significant unfavorable prognostic factor in NSCLC. The information about the proportion of Tregs in the RLNL is considered to be important to overcome the tumor immune escape for development of the effective adjuvant immunotherapy
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Research Products
(10 results)
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[Journal Article] Clinical significance of expression of cancer/testis antigen and down-regulation of HLA class-I in patients with stage I non-small cell lung cancer2013
Author(s)
Hanagiri T, Shigematsu Y, Shinohara S, Takenaka M, Oka S, Chikaishi Y, Nagata Y, Baba T, Uramoto H, So T, Yamada S
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Journal Title
Anticancer Res
Volume: 33
Pages: 2123-8
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[Journal Article] Clinical significance of the frequency of regulatory T cells in regional lymph node lymphocytes as a prognostic factor for non-small-cell lung cancer2013
Author(s)
Hanagiri T, Shigematsu Y, Shinohara S, Takenaka M, Oka S, Chikaishi Y, Nagata Y, Iwata T, Uramoto H, So T, Tanaka F
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Journal Title
Lung Cancer
Volume: 81
Pages: 475-9
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[Journal Article] Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer2013
Author(s)
Hanagiri T, Shigematsu Y, Kuroda K, Baba T, Shiota H, Ichiki Y, Nagata Y, Yasuda M, Uramoto H, So T, Takenoyama M, Tanaka F
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Journal Title
J Surg Res
Volume: 181
Pages: e57-63
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[Journal Article] Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes2012
Author(s)
Shigematsu Y, Hanagiri T, Shiota H, Kuroda K, Baba T, Ichiki Y, Yasuda M, Uramoto H, Takenoyama M, Yasumoto K, Tanaka F
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Journal Title
Oncol Lett
Volume: 4
Pages: 625-630
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[Presentation] 肺癌所属リンパ節における制御性T細胞の臨床病理学的意義2012
Author(s)
花桐武志,重松義紀,竹中賢,岡壮一,近石泰弘,下川秀彦,中川誠,永田好香,岩田輝男,浦本秀隆,宗知子,田中文啓
Organizer
日本肺癌学会
Year and Date
20121108-09
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[Presentation] 肺癌所属リンパ節における制御性T細胞および微小リンパ節転移の解析2012
Author(s)
花桐武志,重松義紀,竹中賢,岡壮一,近石泰弘,下川秀彦,中川誠,永田好香,浦本秀隆,宗知子,田中文啓
Organizer
日本癌治療学会
Year and Date
20121025-27
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[Presentation] 非小細胞肺癌における癌精巣抗原発現とワクチン療法への応用2012
Author(s)
重松義紀,竹中賢,岡壮一,近石泰弘,馬場哲郎,下川秀彦,中川誠,浦本秀隆,宗知子,花桐武志,田中文啓
Organizer
日本外科学会
Year and Date
20120412-14
