2013 Fiscal Year Final Research Report
Prevention of Vascular Restenosis After Vascular Angioplasty by Endothelial specific BNCT
| Project/Area Number |
23592084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Akira 筑波大学, 医学医療系, 教授 (90241819)
YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505)
YOSHIDA Fumiyo 筑波大学, 医学医療系, 助教 (30261811)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳血管内外科学 / ホウ素中性子捕捉療法 / リポソーム |
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| Research Abstract |
We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron containing liposome. The liposome is expected that have EPR effect and adhesive property by sizing and surface modification. Cells were cultured with B containing medium, and neutron irradiation revealed the radiobiological effect of boron neutron capture. borocaptate sodium solution was encapsulated in this liposome, then it achieves the 2.5 times higher boron concentration than nano-particle only.
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[Journal Article] ntra-tumor Distribution of Metallofullerene Using Micro-particle induced X-ray Emission (PIXE)2014
Author(s)
Y. Yamamoto, T. Yamamoto, Y. Horiguchi, K. Endo, M. Shirakawa, T. Miyakawa , A. Matsumura H. Satoh, M. Koka, K. Nakai, Y. Nagasaki, A. Matsumura
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Journal Title
Applied Radiation and isotope
DOI
Peer Reviewed
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