2013 Fiscal Year Final Research Report
The development of prediction system for treatment effect
| Project/Area Number |
23592091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURISU Kaoru 広島大学, 医歯薬保健学研究院, 教授 (70201473)
YAMASAKI Fumiyuki 広島大学, 医歯薬保健学研究院, 助教 (60444692)
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| Project Period (FY) |
2011 – 2013
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| Keywords | glioma / glioblastoma / pseudo-response / DWI / proton MR spectroscopy / ADC / VEGF |
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| Research Abstract |
The single voxel 1HMRS detection of lactate is a prognostic factor in patients with diffuse intrinsic pontine glioma. Calculating the apparent diffusion coefficient value is useful for distinguishing lymphoma from glioblastoma. High b-value DWI reflects cell density more accurately than regular b-value DWI at 3 tesla MRI. It was easier to identify pseudo-responses with RANO- than MacDonald criteria, however the reduction of edema by bevacizumab rendered the early diagnosis of tumor progression difficult by RANO criteria. In some patients with recurrent glioma treated with bevacizumab, high b-value DWI criteria did, while McDonald- and RANO criteria did not identify pseudo-responses at an early point after the start of therapy. In patients with recurrent glioma, high b-value DWI criteria are useful for the differentiation between pseudo- and true responses to treatment with bevacizumab.
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[Journal Article] A Multicenter Phase I/II Study of the BCNU Implant (Gliadel® Wafer) for Japanese Patients with Malignant Gliomas2014
Author(s)
Aoki T, Nishikawa R, Sugiyama K, Nonoguchi N, Kawabata N, Mishima K, Adachi JI, Kurisu K, Yamasaki F, Tominaga T, Kumabe T, Ueki K, Higuchi F, Yamamoto T, Ishikawa E, Takeshima H, Yamashita S, Arita K, Hirano H, Yamada S, Matsutani M
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Journal Title
Neurol Med Chir (Tokyo)
Volume: 54
Pages: 290-291
Peer Reviewed
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[Journal Article] Cancer-specific health-related quality of life in children with brain tumors2013
Author(s)
Sato I, Higuchi A, Yanagisawa T, Mukasa A, Ida K, Sawamura Y, Sugiyama K, Saito N, Kumabe T, Terasaki M, Nishikawa R, Ishida Y, Kamibeppu K
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Journal Title
Qual Life Res
Volume: 23
Pages: 1059-1068
Peer Reviewed
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[Journal Article] Electrocorticographic-histopathologic correlations implying epileptogenicity of dysembryoplastic neuroepithelial tumor2013
Author(s)
Kagawa K, Iida K, Kakita A, Katagiri M, Nishimoto T, Hashizume A, Kiura Y, Hanaya R, Sugiyama K, Arihiro K, Arita K, Kurisu K
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Journal Title
Neurol Med Chir (Tokyo)
Volume: 53
Pages: 676-687
Peer Reviewed
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[Journal Article] Factors influencing self- and parent-reporting health-related quality of life in children with brain tumors2013
Author(s)
Sato I, Higuchi A, Yanagisawa T, Mukasa A, Ida K, Sawamura Y, Sugiyama K, Saito N, Kumabe T, Terasaki M, Nishikawa R, Ishida Y, Kamibeppu K
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Journal Title
Qual Life Res
Volume: 22
Pages: 185-201
Peer Reviewed
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[Journal Article] Lymphomas and glioblastomas : differences in the apparent diffusion coefficient evaluated with high b-value diffusion-weighted magnetic resonance imaging at 3T2012
Author(s)
Doskaliyev A, Yamasaki F, Ohtaki M, Kajiwara Y, Takeshima Y, Watanabe Y, Takayasu T, Amatya VJ, Akiyama Y, Sugiyama K, Kurisu K
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Journal Title
Eur J Radiol
Volume: 81
Pages: 339-344
Peer Reviewed
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[Journal Article] Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma2012
Author(s)
Nagane M, Nishikawa R, Narita Y, Kobayashi H, Takano S, Shinoura N, Aoki T, Sugiyama K, Kuratsu J, Muragaki Y, Sawamura Y, Matsutani M
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Journal Title
Jpn J Clin Oncol
Volume: 42
Pages: 887-95
Peer Reviewed
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[Journal Article] A case of central nervous system lymphomatoid granulomatosis successfully treated with corticosteroids2012
Author(s)
Shimada S, Ueno H, Yamasaki F, Sugiyama K, Yasutomi H, Sekine M, Ohshita T, Kurashige T, Nakamura T, Nishihara H, Yamawaki T, Kurisu K, Matsumoto M
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Journal Title
Brain Nerve
Volume: 64
Pages: 85-87
Peer Reviewed
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[Journal Article] A multicenter phase I trial of combination therapy with interferon-βand temozolomide for high-grade gliomas (INTEGRA study): the final report2011
Author(s)
Wakabayashi T, Kayama T, Nishikawa R, Takahashi H, Hashimoto N, Takahashi J, Aoki T, Sugiyama K, Ogura M, Natsume A, Yoshida J
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Journal Title
J Neurooncol
Volume: 104
Pages: 573-577
Peer Reviewed
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