Paho-physiologocal study for moyamoya disease : proteomix and neuroimaging analysis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kurume University
• Principal Investigator: MORIOKA Motohiro 久留米大学, 医学部, 教授 (20295140)
• Co-Investigator(Kenkyū-buntansha): KURATSU Junichi 熊本大学, 生命科学研究部, 教授 (20145296) ; YANO Shigetoshi 熊本大学, 生命科学研究部, 准教授 (60332871) ; HIDE Takuichiro 熊本大学, 医学部附属病院, 助教 (40421820) ; KAWANO Takayuki 熊本大学, 生命科学研究部, 助教 (50448536) ; HASEGAWA Yu 熊本大学, 生命科学研究部, 助教 (40599114)
• Project Period (FY): 2011 – 2013
• Keywords: もやもや病 / MRI / 血管病理

Research Abstract

We studied the arterial pathophysiology of moyamoya disease. We evaluated 3D-CISS MRI studies of 16 patients with MMD, 8 with atherosclerotic middle cerebral artery stenosis, and 27 control subjects. We compared the outside diameter of the intracranial arteries in these 3 groups.The outside diameter of the internal carotid- and the middle cerebral artery (ICA, M1) in the MMD group was significantly smaller than in the other 2 groups (p < 0.05). Furthermore, the outside diameter was unrelated to the progression of internal canal stenosis grade evaluated from digital subtraction angiography.
Ours is the first 3D-CISS MRI documentation that in MMD patients, a decrease in the outer diameter of the ICA and M1 precedes the decrease in the inside stenotic change of these vessels. We suggest that changes in the ICA and M1 precede the manifestation of interior pathologial stenosis and may constitute the first step in MMD progression.

Research Products

• [Journal Article] Unusual hemodynamic stroke related to an accessory middle cerebral artery : The usefulness of fusion images from three-dimensional angiography (2014)
  • Author(s): Noguchi K, Aoki T, Komaki S, Takeuchi Y, Hirohata M, Morioka M
  • Journal Title: Surg Neurol Int Volume: 5 Pages: 26
  • DOI: 10.4103/2152-7806.127890.
  • Peer Reviewed
• [Journal Article] Outer-diameter narrowing of the internal carotid and disease detected on 3D constructive interference in steady-state MR remodeling a major pathogenesis? (2014)
  • Author(s): Kaku Y, Morioka M, Ohmori Y, Kawano T, Kai Y, Fukuoka H, Hirai T, Yamashita Y, Kuratsu J
  • Journal Title: Acta Neurochir(Wien) Volume: 154(12) Pages: 2151-2157
  • DOI: 10.1007/s00701-012-1472-4
  • Peer Reviewed
• [Journal Article] Prolonged and regionally progressive symptomatic cerebral hyperperfusion syndrome after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease (2012)
  • Author(s): Takemoto Y, Morioka M, Nakagawa T, Hasegawa Y, Ohmori Y, Kawano T, Kai Y, Kuratsu J
  • Journal Title: Surg Neurol Int Volume: 3 Pages: 106
  • DOI: 10.4103/2152-7806.100867.
  • Peer Reviewed
• [Journal Article] Quantitative blood flow measurements in gliomas using arterial spin-labeling at 3T : intermodality agreement and inter- and intraobserver reproducibility study (2011)
  • Author(s): Hirai T, Kitajima M, Nakamura H, Okuda T, Sasao A, Shigematsu Y, Utsunomiya D, Oda S, Uetani H, Morioka M, Yamashita Y
  • Journal Title: AJNR Am J Neuroradiol Volume: 32(1) Pages: 2073-2079
  • DOI: 10.3174/ajnr.A2725
  • Peer Reviewed
• [Journal Article] Granulocyte-colony stimulating factor enhances the angiogenetic effect of indirect bypass surgery for chronic cerebral hypoperfusion in a rat model (2011)
  • Author(s): Ohmori Y, Morioka M, Kaku Y, Kawano T, Kuratsu J
  • Journal Title: Neurosurgery Volume: 68 Pages: 1372-1379
  • DOI: 10.1227/NEU.0b013e31820c0289
  • Peer Reviewed
• [Presentation] Outer-diameter narrowing of the internal carotid and middle cerebral arteries in moyamoya disease : Arterial constrictive remodeling is a major pathogenesis? (2013)
  • Author(s): Morioka M, Kaku Y, Aoki T, Ohmori Y, Kawano T, Kuratsu J
  • Organizer: 3rd International Moyamoya Meeting
  • Place of Presentation: Sapporo
  • Year and Date: 20130712-13
• [Presentation] Microsurgical treatment of cerebral arteriovenous malformation.(Special Lecture) (2013)
  • Author(s): Morioka M
  • Organizer: The 31th Annual Spring Meeting of the Korean Neurosurgical Society
  • Place of Presentation: Daegu
  • Year and Date: 20130411-13
• [Presentation] Surgical approach for cerebrovascular lesion located in the frontal aspect of cervico-medullary junction (2013)
  • Author(s): Morioka M
  • Organizer: 15th World Congress of Neurosurgery(WFNS)
  • Place of Presentation: Seoul
  • Year and Date: 2013-08-13