2013 Fiscal Year Final Research Report
A development of the treatment method without direct bypass for cerebral hypoperfusion
| Project/Area Number |
23592098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
OHMORI Yuki 熊本大学, 医学部附属病院, 非常勤診療医師 (60599116)
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| Co-Investigator(Kenkyū-buntansha) |
KURATSU Jun-ichi 熊本大学, 大学院生命科学研究部, 教授 (20145296)
MORIOKA Motohiro 久留米大学, 医学部, 教授 (20295140)
YANO Shigetoshi 熊本大学, 大学院生命科学研究部, 准教授 (60332871)
KAWANO Takayuki 熊本大学, 大学院生命科学研究部, 助教 (50448536)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性脳血流低下 / G-CSF / 血管新生 / 間接血行再建術 |
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| Research Abstract |
Chronic cerebral hypoperfusion is found in diseases such as major intracranial artery stenosis or occlusion and moyamoya disease. Chronic hypoperfusion conditions often cause cerebral infarction and Cognitive dysfunction. It is expected that the number of patients increases due to the acceleration of aging in the future. Therefore we studied in order to develop a minimally invasive and effective treatment. There were significant angiogenic effect when we performed indirect revascularization and administered G-CSF in chronic cerebral hypoperfusion rat model. Moreover, it was found that the angiogenic effect of superficial temporal artery and the middle meningeal artery was high when we evaluated the chronic cerebral hypoperfusion patients by cerebral angiography after direct and indirect revascularization. Therefore, it was suggested strongly that the method we have performed in animal experiments might be effective in clinically.
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