2013 Fiscal Year Final Research Report
Inflammation and platelet aggregation may be related to delayed ischemic neurological deficits after subarachnoid hemorrhage
| Project/Area Number |
23592103
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | くも膜下出血 / 脳血管攣縮 / 食欲 / アドレノメデュリン / 炎症 / 血小板 |
|---|
| Research Abstract |
Adrenomedullin (AM) is secreted into the cerebrospinal fluid (CSF) from the choroid plexus and regulates appetite. AM concentration in the CSF is elevated 7–10 days after the onset of aneurysmal subarachnoid hemorrhage (SAH). All outcome variables were measured at an early (Day 3) and late (Day 8) time point after SAH onset (Day 0). Dietary oral calorie intake, self-reported appetite level, hemoglobin, albumin, glucose, and insulin levels were lower at the late time point than at the early time point. CSF AM concentration was higher at the late time point than at the early time point. There was a significant negative correlation between AM concentration and dietary oral calorie intake and self-reported appetite level at the late time point. Six patients (27%) developed DIND. AM concentration at the late time point was significantly higher in patients who developed DIND than in patients who did not. CSF AM concentration 8 days after SAH onset is related to appetite loss and DIND.
|
-
-
-
[Journal Article] Postoperative increase in cerebral white matter fractional anisotropy on diffusion tensor magnetic resonance imaging is associated with cognitive improvement after uncomplicated carotid endarterectomy : tract-based spatial statistics analysis2013
Author(s)
Sato Y, Ito K, Ogasawara K, Sasaki M, Kudo K, Murakami T, Nanba T, Nishimoto H, Yoshida K, Kobayashi M, Kubo Y, Mase T, Ogawa A
-
Journal Title
Neurosurgery
Volume: 73(4)
Pages: 592-8
-
[Journal Article] Detection of misery perfusion in the cerebral hemisphere with chronic unilateral major cerebral artery steno-occlusive disease using crossed cerebellar hypoperfusion : comparison of brain SPECT and PET imaging2013
Author(s)
Matsumoto Y, Ogasawara K, Saito H, Terasaki K, Takahashi Y, Ogasawara Y, Kobayashi M, Yoshida K, Beppu T, Kubo Y, Fujiwara S, Tsushima E, Ogawa A
-
Journal Title
Eur J Nucl Med Mol Imaging
Volume: 40(10)
Pages: 1573-81
-
-
[Journal Article] Postoperative changes in cerebral metabolites associated with cognitive improvement and impairment after carotid endarterectomy : a 3T proton MR spectroscopy study2013
Author(s)
Saito H, Ogasawara K, Nishimoto H, Yoshioka Y, Murakami T, Fujiwara S, Sasaki M, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Ogawa A
-
Journal Title
AJNR Am Neuroradiol
Volume: 34(5)
Pages: 976-82
-
-
-
-
-
[Journal Article] Accuracy of central benzodiazepine receptor binding potential/cerebral blood flow SPECT imaging for detecting misery perfusion in patients with unilateral major cerebral artery occlusive diseases : comparison with cerebrovascular reactivity to acetazolamide and cerebral blood flow SPECT imaging2012
Author(s)
Kuroda H, Ogasawara K, Suzuki T, Chida K, Aso K, Kobayashi M, Yoshida K, Terasaki K, Fujiwara S, Kubo Y, Ogawa A
-
Journal Title
Clin Nucl Med
Volume: 37(3)
Pages: 235-40
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
