2014 Fiscal Year Final Research Report
ARF-BP1 expression in malignant brain tumors
| Project/Area Number |
23592116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
USUI Hiroshi 新潟大学, 脳研究所, 非常勤研究員 (20192510)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | ARF-BP1 / mdm2 / p53 / glioma / germ cell tumor / germinoma |
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| Outline of Final Research Achievements |
ARF-BP1 was expressed in parts of glioma tissues, and glioma-derived cell lines in each levels. But there was no relationship between ARF-BP1 expression and the histological differentiation, the histological malignancy, the status of p53 gene mutation, or the status of mdm2 expression of glioma. ARF-BP1 was highly and frequently expressed in germ cell tumors, especially in Germinoma. ARF-BP1 seems to be one of the key molecules in the pathogenesis of germ cell tumors in the brain.
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| Free Research Field |
脳腫瘍
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