2013 Fiscal Year Final Research Report
Predictive/prognostic factors and escape phenomenon on WT1 peptide vaccination against malignant gliomas
| Project/Area Number |
23592123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
HASHIMOTO Naoya 大阪大学, 医学(系)研究科(研究院), 准教授 (90315945)
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| Co-Investigator(Kenkyū-buntansha) |
TSUBOI Akihiro 大阪大学, 医学系研究科, 寄附講座准教授 (10372608)
KINOSHITA Manabu 大阪府立成人病センター, 医長 (40448064)
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| Project Period (FY) |
2011 – 2013
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| Keywords | WT1 / ペプチドワクチン / 悪性神経膠腫 / 治療反応性 / 予後因子 / 脳腫瘍学 |
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| Research Abstract |
We have tried to reveal the predictive or prognostic factors on WT1 peptide vaccination against malignant gliomas. As those factors, a phenotype of memory T cells in periphera blood, high expression of WT1 mRNA, an early positive turning of DTH and methionine parametric response map (PRM) were confirmed. We have also shown that the escape phenomena from WT1 vaccination was in part due to a decrease of WT1/HLA class I molecule expression and an increase of Treg in tumor microenvironment.
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[Journal Article] Different spatial distribution between germinal center B and non-germinal center B primary central nervous system lymphoma revealed by magnetic resonance group analysis2014
Author(s)
Kinoshita M, Sasayama T, Narita Y, Yamashita F, Kawaguchi A, Chiba Y, Kagawa N, Tanaka K, Kohmura E, Arita H, Okita Y, Ohno M, Miyakita Y, Shibui S, Hashimoto N, Yoshimine T
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Journal Title
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[Journal Article] HLA-DPB1*05: 01-restricted WT1332-specific TCR-transduced CD4+ T lymphocytes display a helper activity for WT1-specific CTL induction and a cytotoxicity against leukemia cells2013
Author(s)
Lin Y, Fujiki F, Katsuhara A, Oka Y, Tsuboi A, Aoyama N, Tanii S, Nakajima H, Tatsumi N, Morimoto S, Tamanaka T, Tachino S, Hosen N, Nishida S, Oji Y, Kumanogoh A, Sugiyama H
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Journal Title
JImmunother
Volume: 36(3)
Pages: 159-70
DOI
Peer Reviewed
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[Journal Article] Functional human Th17 clones with WT1-specific helper activity2013
Author(s)
Tachino S, Fujiki F, Oka Y, Tsuboi A, Morimoto S, Lin YH, Tamanaka T, Kondo K, Nakajima H, Nishida S, Hosen N, Oji Y, Kumanogoh A, Sugiyama H.
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Journal Title
Cancer Immunol Immunother
Volume: 62(4)
Pages: 801-10
DOI
Peer Reviewed
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[Journal Article] A novel PET index, 18F-FDG-11C-methionine uptake decoupling score, reflects glioma cell infiltration2012
Author(s)
Kinoshita M, Arita H, Goto T, Okita Y, Isohashi K, Watabe T, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
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Journal Title
J Nucl Med
Volume: 53(11)
Pages: 1701-8
DOI
Peer Reviewed
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[Journal Article] Clinical characteristics of meningiomas assessed by (11)C-methionine and (18)F-fluorodeoxyglucose positron-emission tomography2012
Author(s)
Arita H, Kinoshita M, Okita Y, Hirayama R, Watabe T, Ishohashi K, Kijima N, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T
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Journal Title
J Neurooncol.
Volume: 107(2)
Pages: 379-386
Peer Reviewed
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[Journal Article] Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma2012
Author(s)
Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T
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Journal Title
J Neurosurg
Volume: 116(4)
Pages: 835-842
Peer Reviewed
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[Journal Article] Slower growth of skull base meningiomas compared with non-skull base meningiomas based on volumetric and biological studies2012
Author(s)
Hashimoto N, Rabo CS, Okita Y, Kinoshita M, Kagawa N, Fujimoto Y, Morii E, Kishima H, Maruno M, Kato A, Yoshimine T
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Journal Title
J Neurosurg
Volume: 116(3)
Pages: 574-580
Peer Reviewed
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[Journal Article] ^<18>F-fluorodeoxy glucose/^<11>C-methionine uptake decoupling for identification of tumor cell infiltration in peritumoral brain edema2012
Author(s)
Kinoshita M, Goto T, Arita H, Okita Y, Isohashi K, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Saitoh Y, Hatazawa J, Hashimoto N, Yoshimine T
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Journal Title
J Neurooncol
Volume: 106(2)
Pages: 417-25
Peer Reviewed
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[Journal Article] Biased usage of T cell receptorβ-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8(+) T cells in patients with solid tumors and healthy donors2012
Author(s)
Morimoto S, Oka Y, Tsuboi A, Tanaka Y, Fujiki F, Nakajima H, Hosen N, Nishida S, Nakata J, Nakae Y, Maruno M, Myoui A, Enomoto T, Izumoto S, Sekimoto M, Kagawa N, Hashimoto N, Yoshimine T, Oji Y, Kumanogoh A, Sugiyama H
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Journal Title
Cancer Sci
Volume: 103(3)
Pages: 408-414
Peer Reviewed
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[Journal Article] A multicenter phase I trial of combination therapy with interferon-βand temozolomide for high-grade gliomas (INTEGRA study): the final report2011
Author(s)
Wakabayashi T, Kayama T, Nishikawa R, Takahashi H, Hashimoto N, Takahashi J, Aoki T, Sugiyama K, Ogura M, Natsume A, Yoshida J
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Journal Title
J Neurooncol
Volume: 104(2)
Pages: 573-7
Peer Reviewed
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