2013 Fiscal Year Final Research Report
Combination therapy of oncolytic virus & antiangiogenic drug for malignant glioma
| Project/Area Number |
23592125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOKUNAGA Koji 岡山大学, 医歯薬学総合研究科, 准教授 (40294467)
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| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 医歯薬学総合研究科, 教授 (70236785)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳腫瘍学 / 腫瘍溶解性ウイルス |
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| Research Abstract |
Oncolytic viral (OV) therapy has been considered as a promising treatment modality for brain tumors. Vasculostatin, the fragment of brain-specific angiogenesis inhibitor-1, shows anti-angiogenic activity against malignant gliomas. Previously, a vasculostatinexpressing oncolytic herpes simplex virus-1, Rapid Antiangiogenesis Mediated By Oncolytic virus (RAMBO), was reported to have a potent antitumor effect. Here, we investigated the therapeutic efficacy of RAMBO and cilengitide, an integrin inhibitor, combination therapy for malignant glioma. In vitro, RAMBO, combined with cilengitide, induced synergistic cytotoxicity on glioma cells. In vivo, there was a significant increase in the survival of mice treated with combination therapy compared with RAMBO or cilengitide monotherapy. These results indicate that cilengitide enhanced vasculostatinexpressing OV therapy for malignant glioma and provide a rationale for designing future clinical trials combining these two agents.
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[Presentation] 2013.07.05 Induction of an angiogenec factor, CYR61, in oncolytic viral therapy for malignant gliomas2013
Author(s)
Kurozumi K , Ichikawa T , Fujii K , Shimazu Y , Onishi M , Ishida J , Chiocca EA , Kaur B , Date I
Organizer
第19回日本遺伝子治療学会年次学術集会(The 19th Annual Meeting of Japan Society of Gene Therapy)
Place of Presentation
岡山
Year and Date
2013-07-05
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[Presentation] Multiple mechanisms of cilengitide treatment for malignant glioma2012
Author(s)
33. :, 2012.04.20-22 Kurozumi K , Ichikawa T , Onishi M , Fujii K , Shimazu Y , Ishida J , Chiocca EA , Kaur B , Date I
Organizer
The 9th Meeting of Asian Society for Neuro-Oncology
Place of Presentation
Taipei, Taiwan
Year and Date
20120420-22
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