Development of boron-conjugate targeting adenovirus vector for novel boron neutron capture therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 23592126
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Hiroshima University
• Principal Investigator: HAMA Seiji 広島大学, 医歯薬保健学研究院(医), 研究員 (40397980)
• Co-Investigator(Kenkyū-buntansha): KURISU Kaoru 広島大学, 医歯薬保健学研究科, 教授 (70201473) ; HOSHI Masaharu 広島大学, 平和科学研究センター, 名誉教授 (50099090) ; NISHIMOTO Takeshi 広島大学, 病院, 医科診療医 (40450580)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: ホウ素中性子捕捉療法 / 悪性グリオーマ / アデノウイルスベクター / 放射線治療 / ホウ素化合物 / 電子顕微鏡

Outline of Final Research Achievements

We have conducted the research using adenovirus vector in order to enhance the effect of Boron neutron capture therapy (BNCT) for malignant brain tumor patients. At first, the gold colloid were bound on the surface of adenovirus vector using the binding reaction between thiol group (adenovirus vector surface) - maleimide compound (gold colloid). Then we confirmed that the glima cells were infected with gold colloid binding adenovirus vector using electronic microscope (EM). While ready-made boron compound could not be induced sufficient doses of intra-cellular boron using the adenovirus vector infection. Thus we are now proceeding with the synthesis of novel boron compound in order to improve binding efficiency on the adenovirus surface, lead to construct novel drug delivery system for BNCT.

Free Research Field

脳神経外科学