2013 Fiscal Year Final Research Report
Investigation of molecular genetic alterations and prognostic factors of primary central nervous system lymphoma
| Project/Area Number |
23592140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGANE Motoo 杏林大学, 医学部, 教授 (60327468)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 悪性リンパ腫 / 脳腫瘍 / 遺伝子解析 / 予後因子 / 治療感受性 / Germinal center / MGMT / Mismatch repair |
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| Research Abstract |
We investigated prognostic markers for primary central nervous system lymphoma (PCNSL) using immunohistochemistry. Age and KPS were strong prognosticators as reported previously. Methotrexate-based chemoradiotherapy achieved a high rate of complete response (83%), improving survival of PCNSL patients. Multiplicity of PCNSL lesions was significantly associated with a short survival. High expression of LRP, drug efflux pump protein, was associated with a poor response to chemotherapy and shorter overall survival, suggesting that LRP may be a clinically relevant drug-resistance factor in PCNSL. Expression of a germinal center marker Bcl-6 was a favorable prognostic factor, whereas c-myc high protein expression was associated with an inferior survival. Low protein expression of mismatch repair proteins, MLH1, MSH2 and MSH6, was a significant indicator for a short survival in patients with PCNSL.
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