Pathogenesis and treatment of cognitive dysfunction induced by reduced clearance of cerebrospinal fluid associated with aging

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592142
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Juntendo University
• Principal Investigator: MIYAJIMA Masakazu 順天堂大学, 医学部, 准教授 (60200177)
• Project Period (FY): 2011 – 2013
• Keywords: 老化 / 髄液 / 認知機能障害 / 水頭症 / クリアランス

Research Abstract

The function of LRG in the brain during aging and neurodegenerative diseases has not been investigated. Here, we observed hLRG expression in post-mortem human cerebral cortex. We then generated transgenic mice that over-expressed mouse LRG in the brain to examine the effects of mLRG accumulation. Our results show that in both humans and mouse brains, LRG increases with age. Increased LRG in neurons and glial cells was associated with mouse cerebral cortex neurodegeneration.

Research Products

• [Journal Article] Leucine-richα2-glycoprotein is a novel biomarker of neurodegenerative disease in human cerebrospinal fluid and causes neurodegeneration in mouse cerebral cortex (2013)
  • Author(s): Miyajima M, Nakajima M, Motoi Y, Moriya M, Sugano H, Ogino I, Nakamura E, Tada N, Kunichika M, Arai H
  • Journal Title: PLoS One Volume: 18,8(9) Pages: e74453
• [Journal Article] Brain localization of leucine-richα2-glycoprotein and its role (2012)
  • Author(s): Nakajima M, Miyajima M, Ogino I, Watanabe M, Hagiwara Y, Segawa T, Kobayashi K, Arai H
  • Journal Title: Acta Neurochir Suppl Volume: 113 Pages: 97-101
• [Presentation] Leucine-richα2-glycoprotein (LRG) is a novel biomarker of neurogenerative disease in human cerebrospinal fluid and causes neurodegeneration in mouse cerebral cortex (2013)
  • Author(s): Miyajima M
  • Organizer: Hydrocephalus
  • Place of Presentation: Athens
  • Year and Date: 20130700