2013 Fiscal Year Final Research Report
New treatment using bevacizumab and novel diagnostic method for radiation necrosis
| Project/Area Number |
23592145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWABATA Shinji 大阪医科大学, 医学部脳神経外科, 講師 (20340549)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 放射線壊死 / 血管新生 / ﾍﾞﾊﾞｼｽﾞﾏﾌﾞ / アミノ酸PET / 炎症 / 血管内皮増殖因子 |
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| Research Abstract |
There was a significant correlation between effectiveness of bevacizumab and uptake of F-BPA-PET in radiation necrosis. Reduction of perilesional edema by bevacizumab contributed to improvement of performance status in patients with radiation necrosis. In pathological study, reactive astrocytes and monocytes played important roles, expressing HIF-1alfa, VEGF, CXCR4, CXCL12, PDGR, and PDGF-R. We have still tried to establish experimental radiation necrosis in rats.
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Research Products
(27 results)
