2013 Fiscal Year Final Research Report
Therapeutic effect improvement by new boron neutron capture therapy with amino acid - BSH
| Project/Area Number |
23592146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FURUSE Motomasa 大阪医科大学, 医学部, 講師 (70340560)
IKEDA Naokado 大阪医科大学, 医学部, 非常勤講師 (50434775)
MATSUSHITA Yoko 大阪医科大学, 医学部, 助教 (70512094)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳腫瘍学 / 悪性神経膠腫 / 放射線治療 / ホウ素化合物 / 中性子捕捉療法 / 合成アミノ酸 / ドラッグデリバリーシステム |
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| Research Abstract |
Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when non-radioactive Boron-10 is irradiated with low energy thermal neutrons to produce alpha- particles inside one cell level. The L-amino acid transport system in tumor cells is enhanced compared with normal cells. We designed, synthesized and tested boron carrying unnatural amino-acid, ACBC-BSH, as boron drug for BNCT. Curative effect of ACBC-BSH groups was approximately equal to BPA. The reason is that we think that extracellular accumulations of ACBC-BSH indicating that the seemingly high tumor boron concentrations did not represent the true tumor cellular uptake. And we did not compete for the curative effect by using ACBC-BSH together in BPA and accepted meaningful duration of survival time. Difference in drug distribution at the cell level was regarded as the cause. This study suggested the possibility that ACBC-BSH became the drug to add curative effect to.
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[Presentation] 悪性脳腫瘍に対するホウ素中性子捕捉療法10年の経験と近未来像2012
Author(s)
川端信司,宮武伸一,平松亮,松下葉子,古瀬元雅,黒岩敏彦,鈴木実,田中浩基,櫻井良憲,切畑光統,小野公二
Organizer
第50回日本癌治療学会学術集会
Place of Presentation
京都
Year and Date
20121025-27
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[Presentation] Convection Enhanced Delivery (CED)が切り開く高分子ホウ素化合物のBNCTへの応用2012
Author(s)
川端信司,平松亮,宮田至朗,大西恭子,弘田祐己,横山邦夫,宮武伸一,黒岩敏彦,小野公二, Vicente MGH, Barth RF
Organizer
第50回日本癌治療学会学術集会
Place of Presentation
京都
Year and Date
20121025-27
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[Presentation] Background and trial design of the Phase I, open label, dose escalation study for safety and tolerability of boron neutron capture therapy (BNCT) using boronophenylalanine (SPM-011) / accelerator BNCT system (BNCT30) for the patients with recurrent malignant glioma2012
Author(s)
S. Kawabata, M Suzuki, S-I Miyatake, H Tanaka, Y Sakurai, K Uehara, T Hayashi, T Mitsumoto, Y Kikuchi, K Ono. , 2012/9/10-14
Organizer
The 15th International Congress on Neutron Capture Therapy
Place of Presentation
Tsukuba, JAPAN
Year and Date
20120910-14
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[Book] Boron Neutron Capture Therapy as a Treatment Modality for High‑Grade Gliomas.(Malignant Gliomas: RMR V3 I2; Series: Radiation Me dicine Rounds Volume 3 Issue 2, Arnab Chakravarti, Martin Fuss, Charles Thomas, Jr. (Eds.))2012
Author(s)
Rolf F. Barth, M. Graca H. Vicente, Otto K. Harling, Kent J. Riley, Pete r J. Binns, W. S. Kiger III, and Shi nji Kawabata
Total Pages
209-226
Publisher
demosmedical publisging
