2013 Fiscal Year Final Research Report
Development of photodynamic therapy targeted at glioma stem cells
| Project/Area Number |
23592147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAJIMOTO Yoshinaga 大阪医科大学, 医学部, 講師 (30224413)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 光線力学治療 / 5－アミノレブリン酸 / ポルフィリン / 脳腫瘍 / 悪性グリオーマ / がん幹細胞 / ABCG2 |
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| Research Abstract |
Cancer stem cells is a main cause of resistance of various cancer therapies. ABCG2 transporter, which is highly express in cancer stem cells, also transport excessive porphyrin to extra-cellular space. Therefore, controlling ABCG2 may enhance the effect of 5-ALA PDT and may control cancer stem cells.
In this study, we found that more than a half of porphyrin by produced by 5-ALA administration transported to extracellular space, and inhibition of ABCG2 transporter increased intra-cellular porphyrin and enhanced 5-ALA PDT effect. Furthermore, A172 glioma stem cell had a nature of 5-ALA PDT sensitivity, rather than resistance. These results indicated that 5-ALA PDT and/or combined with ABCG2 inhibitor may useful for controlling the cancer stem cells.
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Research Products
(1 results)
