2013 Fiscal Year Final Research Report
Development of a novel therapy by targeting Warburg effect of gliomas.
| Project/Area Number |
23592149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Miyagi Cancer Center Research Institute |
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Principal Investigator |
YAMASHITA YOUZI 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (30420045)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMA Hiroshi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療 法研究部, 部長 (10196462)
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| Project Period (FY) |
2011 – 2013
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| Keywords | グリオーマ / 解糖系 / ワールブルグ効果 / PKM / スプライシング |
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| Research Abstract |
Pre-mRNA splicing of gene encoding pyruvate kinase M (PKM), a glycolytic enzyme, was dys-regulated, so that expression of PKM isoforms switches from normal- to tumor-type in human glioma. This aberrant splicing was associated with increased levels of a splicing modulator. Experiments using cell-lines showed that suppression of the splicing regulator results in partial restoration of expression of a normal-type PKM isoform. Additionally, we developed mice that transduced with a reporter gene enabling us to live-image PKM splicing regulation.
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[Presentation] Ptprz gene encoding a transmembrene-type protein phosphatase is up-regulated by Sox-2 in glioma2013
Author(s)
Yoji Yamashita, Nobuhiro Tanuma, Ichiro Shibahara, Yukihiro Sonoda, Masayuki Kanamori,Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga, Hiroshi Shima, Ryuichi Katakura
Organizer
AACR ANNUAL MEETING 2013
Place of Presentation
Washington,DC
Year and Date
2013-04-06
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